Publication

Preoperative administration of esomeprazole has no influence on frequency of refluxes

Journal Paper/Review - May 1, 2008

Units
PubMed
Doi

Citation
Jeske H, Borovicka J, von Goedecke A, Tiefenthaler W, Hohlrieder M, Heidegger T, Benzer A. Preoperative administration of esomeprazole has no influence on frequency of refluxes. Journal of clinical anesthesia 2008; 20:191-5.
Type
Journal Paper/Review (English)
Journal
Journal of clinical anesthesia 2008; 20
Publication Date
May 1, 2008
Issn Print
0952-8180
Pages
191-5
Brief description/objective

STUDY OBJECTIVE: To examine the effect of esomeprazole in a fixed time setting on gastric content volume, gastric acidity, gastric barrier pressure, and reflux propensity. DESIGN: Randomized, controlled, double-blind trial. SUBJECTS: 21 healthy, ASA I physical status volunteers. INTERVENTION: Esomeprazole was given 12 hours and one hour before investigation. Before the study, a multichannel intraluminal impedance catheter, pH monitoring data logger (PHmetry) catheter, and an intragastric-esophageal manometry catheter were placed nasally after topical anesthesia. MEASUREMENTS: Gastric acidity and gastric content volume were determined by PHmetry after aspiration of gastric contents over a nasogastric tube. Gastroesophageal reflux and intragastric-esophageal barrier pressure were investigated by multichannel intraluminal impedance measurement, PHmetry, and intragastric-esophageal manometry. MAIN RESULTS: The pH of gastric contents was significantly (P < 0.001) higher after esomeprazole (mean [25th-75th percentile], 4.2 [3.9-4.8] vs 2.0 [1.9-2.7]), and gastric content volume was significantly (P < 0.001) lower (5.0 mL [3.0-12.0] vs 15 mL [10.0-25.0]) in comparison to placebo. No significant difference between esomeprazole and placebo was found with respect to number of refluxes per person, duration of reflux, or barrier pressure. CONCLUSION: Esomeprazole in a fixed time setting can markedly increase the pH of gastric contents and decrease gastric content volume, but has no influence on the frequency, duration of refluxes, or gastroesophageal barrier pressure.