BRCA2 germline mutation carrier with five malignancies: a case report.

Publication

BRCA2 germline mutation carrier with five malignancies: a case report.

Journal Paper/Review - Dec 19, 2024

Su Elena, Christinat Yann, McKee Thomas, Azzarello-Burri Silvia, Jochum Wolfram, Fischer Stefanie, Rothermundt Christian

Citation

Su E, Christinat Y, McKee T, Azzarello-Burri S, Jochum W, Fischer S, Rothermundt C. BRCA2 germline mutation carrier with five malignancies: a case report. Hered Cancer Clin Pract 2024; 22:27.

Type

Journal Paper/Review (English)

Journal

Hered Cancer Clin Pract 2024; 22

Publication Date

Dec 19, 2024

Issn Print

1731-2302

Brief description/objective

BRCA2 germline mutations are known to predispose carriers to various cancer types, including breast, ovarian, pancreatic and prostate cancer. An association with melanoma has also been reported. However, the full tumour spectrum associated with BRCA2 mutations, particularly in patients with other concurrent pathogenetic mutations, is unexplored.