Publication

Primary manifestation of small lymphocytic lymphoma in the prostate

Journal Paper/Review - Oct 1, 2009

Units
PubMed
Doi

Citation
Fehr M, Templeton A, Cogliatti S, Aebersold F, Egli F, Gillessen Sommer S, Cathomas R. Primary manifestation of small lymphocytic lymphoma in the prostate. Onkologie 2009; 32:586-8.
Type
Journal Paper/Review (English)
Journal
Onkologie 2009; 32
Publication Date
Oct 1, 2009
Issn Electronic
1423-0240
Pages
586-8
Brief description/objective

BACKGROUND: Infiltration of non-haematopoietic organs by small lymphocytic lymphoma/chronic lymphocytic leukaemia (SLL/CLL) is not unusual in late-stage disease and thus quite frequently encountered in post-mortem examinations. However, primary manifestation of SLL/CLL in the prostate is rarely diagnosed. PATIENTS AND METHODS: We report two cases of primary prostatic SLL/CLL, in one case in combination with prostate carcinoma, and discuss diagnostic pitfalls, pathophysiological mechanisms and therapeutic management, together with an overview of the literature. CONCLUSIONS: Lymphocytic infiltration of the prostate associated with obstructive symptoms is rare but can already occur in very early disease. Microscopically, SLL/CLL infiltration can be distinguished from chronic prostatitis by its pattern of infiltration and by immunohistochemistry. As the incidence of both SLL/CLL and prostatic carcinoma increases with age, composite tumours might occur more often in the future.