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Echinacea Reduces Antibiotics by Preventing Respiratory Infections: A Meta-Analysis (ERA-PRIMA).
Journal Paper/Review - Apr 16, 2024
Gancitano Giuseppe, Mucci Nicola, Stange Rainer, Ogal Mercedes, Vimalanathan Selvarani, Sreya Mahfuza, Booker Anthony, Hadj-Cherif Bushra, Albrich Werner, Woelkart-Ardjomand Karin, Kreft Samo, Vanden Berghe Wim, Hoexter Godehard, Schapowal Andreas, Johnston Sebastian L
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Brief description/objective
Respiratory tract infections (RTIs) are the leading cause of antibiotic prescriptions, primarily due to the risk for secondary bacterial infections. In this study, we examined whether could reduce the need for antibiotics by preventing RTIs and their complications, and subsequently investigated its safety profile. A comprehensive search of EMBASE, PubMed, Google Scholar, Cochrane DARE and clinicaltrials.gov identified 30 clinical trials (39 comparisons) studying for the prevention or treatment of RTIs in 5652 subjects. significantly reduced the monthly RTI occurrence, risk ratio (RR) 0.68 (95% CI 0.61-0.77) and number of patients with ≥1 RTI, RR = 0.75 [95% CI 0.69-0.81] corresponding to an odds ratio 0.53 [95% CI 0.42-0.67]. reduced the risk of recurrent infections (RR = 0.60; 95% CI 0.46-0.80), RTI complications (RR = 0.44; 95% CI 0.36-0.54) and the need for antibiotic therapy (RR = 0.60; 95% CI 0.39-0.93), with total antibiotic therapy days reduced by 70% (IRR = 0.29; 95% CI 0.11-0.74). Alcoholic extracts from freshly harvested were the strongest, with an 80% reduction of antibiotic treatment days, IRR 0.21 [95% CI 0.15-0.28]. An equal number of adverse events occurred with and control treatment. can safely prevent RTIs and associated complications, thereby decreasing the demand for antibiotics. Relevant differences exist between preparations.