Aneurysm wall cellularity affects healing after coil embolization: assessment in a rat saccular aneurysm model.

Publication

Aneurysm wall cellularity affects healing after coil embolization: assessment in a rat saccular aneurysm model.

Journal Paper/Review - Dec 23, 2019

Nevzati Edin, Rey Jeannine, Coluccia Daniel, Grüter Basil Erwin, Wanderer Stefan, vonGunten Michael, Remonda Luca, Frosen Juhana, Widmer Hans Rudolf, Fandino Javier, Marbacher Serge

Citation

Nevzati E, Rey J, Coluccia D, Grüter B, Wanderer S, vonGunten M, Remonda L, Frosen J, Widmer H, Fandino J, Marbacher S. Aneurysm wall cellularity affects healing after coil embolization: assessment in a rat saccular aneurysm model. J Neurointerv Surg 2019; 12:621-625.

Type

Journal Paper/Review (English)

Journal

J Neurointerv Surg 2019; 12

Publication Date

Dec 23, 2019

Issn Electronic

1759-8486

Pages

621-625

Brief description/objective

Despite significant technical advances, recanalization rates after endovascular therapy of ruptured intracranial aneurysms (IAs) remain a clinical challenge. A histopathological hallmark of ruptured human IA walls is mural cell loss. Mural smooth muscle cells (SMCs) are known to promote intraluminal healing in thrombosed experimental aneurysms. In this rat model we assess the natural history and healing process after coil embolization in SMC-rich and decellularized aneurysms.