Parent artery-initiated and stent-mediated neointima formation in a rat saccular side wall model.

Publication

Parent artery-initiated and stent-mediated neointima formation in a rat saccular side wall model.

Journal Paper/Review - Feb 2, 2022

Wanderer Stefan, Grüter Basil Erwin, Boillat Gwendoline, Sivanrupan Sivani, Rey Jeannine, Catalano Kristina, vonGunten Michael, Widmer Hans Rudolf, Andereggen Lukas, Marbacher Serge

Citation

Wanderer S, Grüter B, Boillat G, Sivanrupan S, Rey J, Catalano K, vonGunten M, Widmer H, Andereggen L, Marbacher S. Parent artery-initiated and stent-mediated neointima formation in a rat saccular side wall model. J Neurointerv Surg 2022; 14:1258-1263.

Type

Journal Paper/Review (English)

Journal

J Neurointerv Surg 2022; 14

Publication Date

Feb 2, 2022

Issn Electronic

1759-8486

Pages

1258-1263

Brief description/objective

Unlike clipping that forms an immediate barrier of blood flow into intracranial aneurysms, endovascular treatments rely on thrombus organization and neointima formation. Therefore, a continuous endothelial cell layer is crucial to prevent blood flow in the former aneurysm. This study investigates the origin of endothelial cells in the neointima of endovascular treated aneurysms, specifically whether cells from the parent artery play a role in neointima formation.