The connection of motor improvement after deep brain stimulation in Parkinson's disease and microstructural integrity of the substantia nigra and subthalamic nucleus.

Publication

The connection of motor improvement after deep brain stimulation in Parkinson's disease and microstructural integrity of the substantia nigra and subthalamic nucleus.

Journal Paper/Review - Apr 18, 2024

Hermann Marco G, Schröter Nils, Rau Alexander, Reisert Marco, Jarc Nadja, Rijntjes Michel, Hosp Jonas Aurel, Reinacher Peter C, Jost Wolfgang H, Urbach Horst, Weiller Cornelius, Coenen Volker Arnd, Sajonz Bastian Elmar Alexander

Citation

Hermann M, Schröter N, Rau A, Reisert M, Jarc N, Rijntjes M, Hosp J, Reinacher P, Jost W, Urbach H, Weiller C, Coenen V, Sajonz B. The connection of motor improvement after deep brain stimulation in Parkinson's disease and microstructural integrity of the substantia nigra and subthalamic nucleus. Neuroimage Clin 2024; 42:103607.

Type

Journal Paper/Review (English)

Journal

Neuroimage Clin 2024; 42

Publication Date

Apr 18, 2024

Issn Electronic

2213-1582

Pages

103607

Brief description/objective

Nigrostriatal microstructural integrity has been suggested as a biomarker for levodopa response in Parkinson's disease (PD), which is a strong predictor for motor response to deep brain stimulation (DBS) of the subthalamic nucleus (STN). This study aimed to explore the impact of microstructural integrity of the substantia nigra (SN), STN, and putamen on motor response to STN-DBS using diffusion microstructure imaging.