Long-term outcome of peripheral T-cell lymphomas: Ten-year follow-up of the International Prospective T-cell Project.

Publication

Long-term outcome of peripheral T-cell lymphomas: Ten-year follow-up of the International Prospective T-cell Project.

Journal Paper/Review - Mar 26, 2024

Civallero Monica, Schroers-Martin Joseph G, Horwitz Steven M, Manni Martina, Stepanishyna Yana, Cabrera Maria Elena, Vose Julie M, Spina Michele, Hitz Felicitas, Nagler Arnon, Montoto Silvia, Chiattone Carlos S, Skrypets Tetiana, Perez Saenz M Angeles, Priolo Giorgio, Luminari Stefano, Lymboussaki Athina, Pavlovsky Astrid, Marino Dario, Liberati Marina, Trotman Judith, Mannina Donato, Federico Massimo, Advani Ranjana H

Citation

Civallero M, Schroers-Martin J, Horwitz S, Manni M, Stepanishyna Y, Cabrera M, Vose J, Spina M, Hitz F, Nagler A, Montoto S, Chiattone C, Skrypets T, Perez Saenz M, Priolo G, Luminari S, Lymboussaki A, Pavlovsky A, Marino D, Liberati M, Trotman J, Mannina D, Federico M, Advani R. Long-term outcome of peripheral T-cell lymphomas: Ten-year follow-up of the International Prospective T-cell Project. Br J Haematol 2024; 205:166-174.

Type

Journal Paper/Review (English)

Journal

Br J Haematol 2024; 205

Publication Date

Mar 26, 2024

Issn Electronic

1365-2141

Pages

166-174

Brief description/objective

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of haematological cancers with generally poor clinical outcomes. However, a subset of patients experience durable disease control, and little is known regarding long-term outcomes. The International T-cell Lymphoma Project (ITCLP) is the largest prospectively collected cohort of patients with PTCLs, providing insight into clinical outcomes at academic medical centres globally. We performed a long-term outcome analysis on patients from the ITCLP with available 10-year follow-up data (n = 735). The overall response rate to first-line therapy was 68%, while 5- and 10-year overall survival estimates were 49% and 40% respectively. Most deaths occurred prior to 5 years, and for patients alive at 5 years, the chance of surviving to 10 years was 84%. However, lymphoma remained the leading cause of death in the 5- to 10-year period (67%). Low-risk International Prognostic Index and Prognostic Index for T-cell lymphoma scores both identified patients with improved survival, while in multivariate analysis, age >60 years and Eastern Cooperative Oncology Group performance status 2-4 were associated with inferior outcomes. The favourable survival seen in patients achieving durable initial disease control emphasizes the unmet need for optimal front-line therapeutic approaches in PTCLs.