Hemorrhagic Transformation in Noncardioembolic Acute Ischemic Stroke: MRI Analysis From PACIFIC-STROKE.

Publication

Hemorrhagic Transformation in Noncardioembolic Acute Ischemic Stroke: MRI Analysis From PACIFIC-STROKE.

Journal Paper/Review - May 1, 2024

Chen Chih-Hao, Shoamanesh Ashkan, Colorado Pablo, Saad Feryal, Lemmens Robin, De Marchis Gian Marco, Caso Valeria, Xu Lizhen, Heenan Laura, Masjuan Jaime, Christensen Hanne, Connolly Stuart J, Khatri Pooja, Mundl Hardi, Hart Robert G, Smith Eric Edward

Citation

Chen C, Shoamanesh A, Colorado P, Saad F, Lemmens R, De Marchis G, Caso V, Xu L, Heenan L, Masjuan J, Christensen H, Connolly S, Khatri P, Mundl H, Hart R, Smith E. Hemorrhagic Transformation in Noncardioembolic Acute Ischemic Stroke: MRI Analysis From PACIFIC-STROKE. Stroke 2024

Type

Journal Paper/Review (English)

Journal

Stroke 2024

Publication Date

May 1, 2024

Issn Electronic

1524-4628

Brief description/objective

In the phase 2 PACIFIC-STROKE trial (Proper Dosing and Safety of the Oral FXIa Inhibitor BAY 2433334 in Patients Following Acute Noncardioembolic Stroke), asundexian, an oral factor XIa inhibitor, did not increase the risk of hemorrhagic transformation (HT). In this secondary analysis, we aimed to investigate the frequency, types, and risk factors of HT on brain magnetic resonance imaging (MRI).