Cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis.

Publication

Cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis.

Journal Paper/Review - Mar 11, 2024

Wendebourg Maria Janina, Weigel Matthias, Weidensteiner Claudia, Sander Laura, Kesenheimer Eva, Naumann Nicole, Haas Tanja, Madoerin Philipp, Braun Nathalie, Neuwirth Christoph, Weber Markus, Jahn Kathleen, Kappos Ludwig, Granziera Cristina, Schweikert Kathi, Sinnreich Michael, Bieri Oliver, Schlaeger Regina

Citation

Wendebourg M, Weigel M, Weidensteiner C, Sander L, Kesenheimer E, Naumann N, Haas T, Madoerin P, Braun N, Neuwirth C, Weber M, Jahn K, Kappos L, Granziera C, Schweikert K, Sinnreich M, Bieri O, Schlaeger R. Cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis. Eur J Neurol 2024:e16268.

Type

Journal Paper/Review (English)

Journal

Eur J Neurol 2024

Publication Date

Mar 11, 2024

Issn Electronic

1468-1331

Pages

e16268

Brief description/objective

In amyotrophic lateral sclerosis (ALS), there is an unmet need for more precise patient characterization through quantitative, ideally operator-independent, assessments of disease extent and severity. Radially sampled averaged magnetization inversion recovery acquisitions (rAMIRA) magnetic resonance imaging enables gray matter (GM) and white matter (WM) area quantitation in the cervical and thoracic spinal cord (SC) with optimized contrast. We aimed to investigate rAMIRA-derived SC GM and SC WM areas and their association with clinical phenotype and disability in ALS.