Tacrolimus monitoring in hair samples of kidney transplant recipients.

Publication

Tacrolimus monitoring in hair samples of kidney transplant recipients.

Journal Paper/Review - Dec 4, 2023

Born Alexander, Bocchi Federica, Kuhn Christian, Amstutz Ursula, Baumgartner Matthias R, Sidler Daniel

Citation

Born A, Bocchi F, Kuhn C, Amstutz U, Baumgartner M, Sidler D. Tacrolimus monitoring in hair samples of kidney transplant recipients. Front Med (Lausanne) 2023; 10:1307505.

Type

Journal Paper/Review (English)

Journal

Front Med (Lausanne) 2023; 10

Publication Date

Dec 4, 2023

Issn Print

2296-858X

Pages

1307505

Brief description/objective

Calcineurin inhibitors, including tacrolimus, remain a cornerstone of immunosuppressive therapy after kidney transplantation. However, the therapeutic window is narrow, and nephrotoxic side effects occur with overdose, while the risk of alloimmunization and graft rejection increases with underdose. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) allows quantification of tacrolimus in biological samples from patients. This study investigates the feasibility of quantifying tacrolimus in scalp hair from kidney transplant (KT) recipients and correlates hair tacrolimus concentrations with tacrolimus dosage and blood trough levels. The aim was to provide proof-of-principle for hair tacrolimus drug monitoring in KT recipients.