Exploring the intratumoral heterogeneity of DNA ploidy in prostate cancer.

Publication

Exploring the intratumoral heterogeneity of DNA ploidy in prostate cancer.

Journal Paper/Review - Dec 26, 2023

Vlajnic Tatjana, Muller David C, Ruiz Christian, Schönegg René, Seifert Hans-Helge, Thalmann George N, Zellweger Tobias, Le Magnen Clémentine, Rentsch Cyrill A, Bubendorf Lukas

Citation

Vlajnic T, Muller D, Ruiz C, Schönegg R, Seifert H, Thalmann G, Zellweger T, Le Magnen C, Rentsch C, Bubendorf L. Exploring the intratumoral heterogeneity of DNA ploidy in prostate cancer. Cancer Rep (Hoboken) 2023:e1953.

Type

Journal Paper/Review (English)

Journal

Cancer Rep (Hoboken) 2023

Publication Date

Dec 26, 2023

Issn Electronic

2573-8348

Pages

e1953

Brief description/objective

Prostate cancer is morphologically and molecularly heterogeneous. Genomic heterogeneity might be mirrored by variability in DNA ploidy. Aneuploidy is a hallmark of genomic instability and associated with tumor aggressiveness. Little attention has been paid to the biological significance of the diploid tumor cell population that often coexists with aneuploid populations. Here, we investigated the role of DNA ploidy in tumor heterogeneity and clonal evolution.