Deep Brain Stimulation Improves Parkinson's Disease-Associated Pain by Decreasing Spinal Nociception.

Publication

Deep Brain Stimulation Improves Parkinson's Disease-Associated Pain by Decreasing Spinal Nociception.

Journal Paper/Review - Dec 9, 2023

Mylius Veit, Baars Jan Harald, Witt Karsten, Benninger David H, Ciampi de Andrade D, Kägi Georg, Bally Julien, Brugger Florian

Citation

Mylius V, Baars J, Witt K, Benninger D, Ciampi de Andrade D, Kägi G, Bally J, Brugger F. Deep Brain Stimulation Improves Parkinson's Disease-Associated Pain by Decreasing Spinal Nociception. Mov Disord 2023

Type

Journal Paper/Review (English)

Journal

Mov Disord 2023

Publication Date

Dec 9, 2023

Issn Electronic

1531-8257

Brief description/objective

Dopamine exerts antinociceptive effects on pain in PD at cortical and spinal levels, whereas only cortical effects have been described for DBS, so far. By assessing the nociceptive flexion reflex (NFR) threshold at medication on, and DBS ON and OFF in two patients, we showed that DBS additionally decreases spinal nociception.