Surgical site infections after kidney transplantation are independently associated with graft loss.

Publication

Surgical site infections after kidney transplantation are independently associated with graft loss.

Journal Paper/Review - Nov 30, 2023

Schreiber Peter W, Hoessly Linard D, Boggian Katia, Neofytos Dionysios, Van Delden Christian, Egli Adrian, Dickenmann Michael, Hirzel Cédric, Manuel Oriol, Koller Michael, Rossi Simona, Banz Vanessa M, Schmied Bruno, Gürke Lorenz, Matter Maurice, de Rougemont Olivier, Bonani Marco, Golshayan Délaviz, Schnyder Aurelia, Sidler Daniel, Haidar Fadi, Kuster Stefan, Stampf Susanne, Müller Nicolas J., members of the Swiss Transplant Cohort Study (STCS)

Citation

Schreiber P, Hoessly L, Boggian K, Neofytos D, Van Delden C, Egli A, Dickenmann M, Hirzel C, Manuel O, Koller M, Rossi S, Banz V, Schmied B, Gürke L, Matter M, de Rougemont O, Bonani M, Golshayan D, Schnyder A, Sidler D, Haidar F, Kuster S, Stampf S, Müller N, members of the Swiss Transplant Cohort Study (STCS). Surgical site infections after kidney transplantation are independently associated with graft loss. Am J Transplant 2023

Type

Journal Paper/Review (English)

Journal

Am J Transplant 2023

Publication Date

Nov 30, 2023

Issn Electronic

1600-6143

Brief description/objective

Surgical site infections (SSIs) are common health care-associated infections. SSIs after kidney transplantation (K-Tx) can endanger patient and allograft survival. Multicenter studies on this early posttransplant complication are scarce. We analyzed consecutive adult K-Tx recipients enrolled in the Swiss Transplant Cohort Study who received a K-Tx between May 2008 and September 2020. All data were prospectively collected with the exception of the categorization of SSI which was performed retrospectively according to the Centers for Disease Control and Prevention criteria. A total of 58 out of 3059 (1.9%) K-Tx recipients were affected by SSIs. Deep incisional (15, 25.9%) and organ/space infections (34, 58.6%) predominated. In the majority of SSIs (52, 89.6%), bacteria were detected, most frequently Escherichia coli (15, 28.9%), Enterococcus spp. (14, 26.9%), and coagulase-negative staphylococci (13, 25.0%). A BMI ≥25 kg/m (multivariable OR 2.16, 95% CI 1.07-4.34, P = .023) and delayed graft function (multivariable OR 2.88, 95% CI 1.56-5.34, P = .001) were independent risk factors for SSI. In Cox proportional hazard models, SSI was independently associated with graft loss (multivariable HR 3.75, 95% CI 1.35-10.38, P = .011). In conclusion, SSI was a rare complication after K-Tx. BMI ≥25 kg/m and delayed graft function were independent risk factors. SSIs were independently associated with graft loss.