Publication

Effect of Single High Dose Vitamin D Substitution in Hospitalized COVID-19 Patients with Vitamin D Deficiency on Length of Hospital Stay.

Journal Paper/Review - Apr 25, 2023

Units
PubMed
Doi
Contact

Citation
Jaun F, Boesing M, Lüthi-Corridori G, Abig K, Bloch N, Giezendanner S, Grillmayr V, Haas P, Leuppi-Taegtmeyer A, Muser J, Räss A, Schuetz P, Brändle M, Leuppi J. Effect of Single High Dose Vitamin D Substitution in Hospitalized COVID-19 Patients with Vitamin D Deficiency on Length of Hospital Stay. Biomedicines 2023; 11
Type
Journal Paper/Review (English)
Journal
Biomedicines 2023; 11
Publication Date
Apr 25, 2023
Issn Print
2227-9059
Brief description/objective

Vitamin D and its role in the coronavirus-19 disease (COVID-19) pandemic has been controversially discussed, with inconclusive evidence about vitamin D3 (cholecalciferol) supplementation in COVID-19 patients. Vitamin D metabolites play an important role in the initiation of the immune response and can be an easily modifiable risk factor in 25-hydroxyvitamin D (25(OH)D)-deficient patients. This is a multicenter, randomized, placebo-controlled double-blind trial to compare the effect of a single high dose of vitamin D followed by treatment as usual (TAU) of daily vitamin D daily until discharge versus placebo plus TAU in hospitalized patients with COVID-19 and 25(OH)D-deficiency on length hospital stay. We included 40 patients per group and did not observe a significant difference in the median length of hospital stay (6 days in both groups, = 0.920). We adjusted the length of stay for COVID-19 risk factors (β = 0.44; 95% CI: -2.17-2.22), and center (β = 0.74; 95% CI: -1.25-2.73). The subgroup analysis in patients with severe 25(OH)D-deficiency (<25 nmol/L) showed a non-significant reduction in the median length of hospital stay in the intervention group (5.5 vs. 9 days, = 0.299). The competing risk model with death did not reveal significant differences between the group in the length of stay (HR = 0.96, 95% CI 0.62-1.48, = 0.850). Serum 25(OH)D level increased significantly in the intervention group (mean change in nmol/L; intervention: +26.35 vs. control: -2.73, < 0.001). The intervention with 140,000 IU vitamin D + TAU did not significantly shorten the length of hospital stay but was effective and safe for the elevation of serum 25(OH)D levels.