Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS.

Publication

Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS.

Journal Paper/Review - Dec 13, 2023

Cagol Alessandro, Benkert Pascal, Melie-Garcia Lester, Schaedelin Sabine A, Leber Selina, Tsagkas Charidimos, Barakovic Muhamed, Galbusera Riccardo, Lu Po-Jui, Weigel Matthias, Ruberte Esther, Radue Ernst-Wilhelm, Yaldizli Ozgür, Oechtering Johanna, Lorscheider Johannes, D'Souza Marcus, Fischer-Barnicol Bettina, Müller Stefanie, Achtnichts Lutz, Vehoff Jochen, Giulio Disanto, Findling Oliver, Chan Andrew T, Salmen Anke, Pot Caroline, Bridel Claire, Zecca Chiara, Derfuss Tobias, Lieb Johanna Maria, Remonda Luca, Wagner Franca, Vargas Maria Isabel, Du Pasquier Renaud A, Lalive Patrice H, Pravatà Emanuele, Weber Johannes, Cattin Philippe C, Absinta Martina, Gobbi Claudio, Leppert David, Kappos Ludwig, Kuhle Jens, Granziera Cristina

Citation

Cagol A, Benkert P, Melie-Garcia L, Schaedelin S, Leber S, Tsagkas C, Barakovic M, Galbusera R, Lu P, Weigel M, Ruberte E, Radue E, Yaldizli O, Oechtering J, Lorscheider J, D'Souza M, Fischer-Barnicol B, Müller S, Achtnichts L, Vehoff J, Giulio D, Findling O, Chan A, Salmen A, Pot C, Bridel C, Zecca C, Derfuss T, Lieb J, Remonda L, Wagner F, Vargas M, Du Pasquier R, Lalive P, Pravatà E, Weber J, Cattin P, Absinta M, Gobbi C, Leppert D, Kappos L, Kuhle J, Granziera C. Association of Spinal Cord Atrophy and Brain Paramagnetic Rim Lesions With Progression Independent of Relapse Activity in People With MS. Neurology 2023; 102:e207768.

Type

Journal Paper/Review (English)

Journal

Neurology 2023; 102

Publication Date

Dec 13, 2023

Issn Electronic

1526-632X

Pages

e207768

Brief description/objective

Progression independent of relapse activity (PIRA) is a crucial determinant of overall disability accumulation in multiple sclerosis (MS). Accelerated brain atrophy has been shown in patients experiencing PIRA. In this study, we assessed the relation between PIRA and neurodegenerative processes reflected by (1) longitudinal spinal cord atrophy and (2) brain paramagnetic rim lesions (PRLs). Besides, the same relationship was investigated in progressive MS (PMS). Last, we explored the value of cross-sectional brain and spinal cord volumetric measurements in predicting PIRA.