Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS.

Publication

Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS.

Journal Paper/Review - Apr 9, 2022

Oechtering Johanna, Lincke Therese, Schaedelin Sabine A, Décard Bernhard Friedrich, Maceski Aleksandra Maleska, Orleth Annette, Meier Stephanie, Willemse Eline A J, Buchmann Arabella, Khalil Michael, Derfuss Tobias, Benkert Pascal, Heijnen Ingmar A F M, Regeniter Axel, Müller Stefanie, Achtnichts Lutz, Lalive Patrice H, Salmen Anke, Pot Caroline, Gobbi Claudio, Kappos Ludwig, Granziera Cristina, Leppert David, Schlaeger Regina, Lieb Johanna Maria, Kuhle Jens, Swiss MS Cohort Study

Citation

Oechtering J, Lincke T, Schaedelin S, Décard B, Maceski A, Orleth A, Meier S, Willemse E, Buchmann A, Khalil M, Derfuss T, Benkert P, Heijnen I, Regeniter A, Müller S, Achtnichts L, Lalive P, Salmen A, Pot C, Gobbi C, Kappos L, Granziera C, Leppert D, Schlaeger R, Lieb J, Kuhle J, Swiss MS Cohort Study. Intrathecal IgM Synthesis Is Associated with Spinal Cord Manifestation and Neuronal Injury in Early MS. Ann Neurol 2022; 91:814-820.

Type

Journal Paper/Review (English)

Journal

Ann Neurol 2022; 91

Publication Date

Apr 9, 2022

Issn Electronic

1531-8249

Pages

814-820

Brief description/objective

Intrathecal Immunoglobulin M synthesis (IgM ) and spinal MRI lesions are both strong independent predictors of higher disease activity and severity in multiple sclerosis (MS). We investigated whether IgM is associated with spinal cord manifestation and higher neuroaxonal damage in early MS.