HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44 Natural Killer Cells in Ulcerative Colitis.

Publication

HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44 Natural Killer Cells in Ulcerative Colitis.

Journal Paper/Review - Jul 15, 2023

Baumdick Martin E, Niehrs Annika, Degenhardt Frauke, Schwerk Maria, Hinrichs Ole, Jordan-Paiz Ana, Padoan Benedetta, Wegner Lucy H M, Schloer Sebastian, Zecher Britta F, Malsy Jakob, Joshi Vinita R, Illig Christin, Schröder-Schwarz Jennifer, Möller Kimberly J, Hamburg Intestinal Tissue Study Group, Martin Maureen P, Yuki Yuko, Ozawa Mikki, Sauter Jürgen, Schmidt Alexander, Perez Daniel, Giannou Anastasios D, Carrington Mary, Davis Randall S, Schumacher Udo, Sauter Guido, Huber Samuel, Puelles Victor G, Melling Nathaniel, Klein-Franke Andreas, International Inflammatory Bowel Disease Genetics Consortium, Altfeld Marcus, Bunders Madeleine J, Brand Stephan

Citation

Baumdick M, Niehrs A, Degenhardt F, Schwerk M, Hinrichs O, Jordan-Paiz A, Padoan B, Wegner L, Schloer S, Zecher B, Malsy J, Joshi V, Illig C, Schröder-Schwarz J, Möller K, Hamburg Intestinal Tissue Study Group, Martin M, Yuki Y, Ozawa M, Sauter J, Schmidt A, Perez D, Giannou A, Carrington M, Davis R, Schumacher U, Sauter G, Huber S, Puelles V, Melling N, Klein-Franke A, International Inflammatory Bowel Disease Genetics Consortium, Altfeld M, Bunders M, Brand S. HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44 Natural Killer Cells in Ulcerative Colitis. Gastroenterology 2023; 165:946-962.e13.

Type

Journal Paper/Review (English)

Journal

Gastroenterology 2023; 165

Publication Date

Jul 15, 2023

Issn Electronic

1528-0012

Pages

946-962.e13

Brief description/objective

Ulcerative colitis (UC) is characterized by severe inflammation and destruction of the intestinal epithelium, and is associated with specific risk single nucleotide polymorphisms in HLA class II. Given the recently discovered interactions between subsets of HLA-DP molecules and the activating natural killer (NK) cell receptor NKp44, genetic associations of UC and HLA-DP haplotypes and their functional implications were investigated.