Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis.

Publication

Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis.

Journal Paper/Review - Nov 6, 2023

Abdelhak Ahmed, Benkert Pascal, Schaedelin Sabine A, Boscardin W John, Cordano Christian, Oechtering Johanna, Ananth Kirtana, Granziera Cristina, Melie-Garcia Lester, Montes Shivany Condor, Beaudry-Richard Alexandra, Achtnichts Lutz, Oertel Frederike C, Lalive Patrice H, Leppert David, Müller Stefanie, Henry Roland G, Pot Caroline, Matthias Amandine, Salmen Anke, Oksenberg Jorge R, Giulio Disanto, Zecca Chiara, D'Souza Marcus, Du Pasquier Renaud A, Bridel Claire, Gobbi Claudio, Kappos Ludwig, Hauser Stephen L, Cree Bruce A C, Kuhle Jens, Green Ari J, UCSF, MS EPIC, and the SMSC Study Teams

Citation

Abdelhak A, Benkert P, Schaedelin S, Boscardin W, Cordano C, Oechtering J, Ananth K, Granziera C, Melie-Garcia L, Montes S, Beaudry-Richard A, Achtnichts L, Oertel F, Lalive P, Leppert D, Müller S, Henry R, Pot C, Matthias A, Salmen A, Oksenberg J, Giulio D, Zecca C, D'Souza M, Du Pasquier R, Bridel C, Gobbi C, Kappos L, Hauser S, Cree B, Kuhle J, Green A, UCSF, MS EPIC, and the SMSC Study Teams. Neurofilament Light Chain Elevation and Disability Progression in Multiple Sclerosis. JAMA Neurol 2023

Type

Journal Paper/Review (English)

Journal

JAMA Neurol 2023

Publication Date

Nov 6, 2023

Issn Electronic

2168-6157

Brief description/objective

Mechanisms contributing to disability accumulation in multiple sclerosis (MS) are poorly understood. Blood neurofilament light chain (NfL) level, a marker of neuroaxonal injury, correlates robustly with disease activity in people with MS (MS); however, data on the association between NfL level and disability accumulation have been conflicting.