Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination-A prospective multicentre cohort of health professionals (SURPRISE study).

Publication

Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination-A prospective multicentre cohort of health professionals (SURPRISE study).

Journal Paper/Review - Jun 19, 2023

Kohler Philipp, Babouee Flury Baharak, Güsewell Sabine, Egger Thomas, Leal-Neto Onicio B, Brucher Angela, Lemmenmeier Eva, Meier Kleeb Dorette, Möller J. Carsten, Ortner Manuela, Rieder Philippe, Ruetti Markus, Schmid Hans Ruedi, Stocker Reto, Vuichard-Gysin Danielle, Speer Oliver, Wiggli Benedikt, Besold Ulrike, McGeer Allison J, Risch Lorenz, Friedl Andree, Schlegel Matthias, Vernazza Pietro L, Kahlert Christian, Kuster Stefan, SURPRISE Study Group

Citation

Kohler P, Babouee Flury B, Güsewell S, Egger T, Leal-Neto O, Brucher A, Lemmenmeier E, Meier Kleeb D, Möller J, Ortner M, Rieder P, Ruetti M, Schmid H, Stocker R, Vuichard-Gysin D, Speer O, Wiggli B, Besold U, McGeer A, Risch L, Friedl A, Schlegel M, Vernazza P, Kahlert C, Kuster S, SURPRISE Study Group. Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination-A prospective multicentre cohort of health professionals (SURPRISE study). Influenza Other Respir Viruses 2023; 17:e13167.

Type

Journal Paper/Review (English)

Journal

Influenza Other Respir Viruses 2023; 17

Publication Date

Jun 19, 2023

Issn Electronic

1750-2659

Pages

e13167

Brief description/objective

The effects of different types of pre-existing immunity on the frequency of clinical symptoms caused by the SARS-CoV-2 breakthrough infection were prospectively assessed in healthcare workers during the Omicron period. Among 518 participants, hybrid immunity was associated with symptom reduction for dizziness, muscle or limb pain and headache as compared to vaccination only. Moreover, the frequencies of dizziness, cough and muscle or limb pain were lower in participants who had received a booster vaccine dose. Thus, hybrid immunity appeared to be superior in preventing specific symptoms during breakthrough infection compared to vaccination alone. A booster vaccine dose conferred additional symptom reduction.