Publication
Practical "1-2-3-4-Day" Rule for Starting Direct Oral Anticoagulants After Ischemic Stroke With Atrial Fibrillation: Combined Hospital-Based Cohort Study.
Journal Paper/Review - Feb 2, 2022
Kimura Shunsuke, Toyoda Kazunori, Yoshimura Sohei, Minematsu Kazuo, Yasaka Masahiro, Paciaroni Maurizio, Werring David J, Yamagami Hiroshi, Nagao Takehiko, Yoshimura Shinichi, Polymeris Alexandros A, Zietz Annaelle, Engelter Stefan T, Kallmünzer Bernd, Cappellari Manuel, Chiba Tetsuya, Yoshimoto Takeshi, Shiozawa Masayuki, Kitazono Takanari, Koga Masatoshi, SAMURAI, RELAXED, RAF, RAF-NOAC, CROMIS-2, NOACISP LONGTERM, Erlangen Registry and Verona Registry Investigators
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Brief description/objective
The "1-3-6-12-day rule" for starting direct oral anticoagulants (DOACs) in patients with nonvalvular atrial fibrillation after acute ischemic stroke or transient ischemic attack recommends timings that may be later than used in clinical practice. We investigated more practical optimal timing of DOAC initiation according to stroke severity.