Tranexamic Acid for Intracerebral Hemorrhage in Patients on Non-Vitamin K Antagonist Oral Anticoagulants (TICH-NOAC): A Multicenter, Randomized, Placebo-Controlled, Phase 2 Trial.

Publication

Tranexamic Acid for Intracerebral Hemorrhage in Patients on Non-Vitamin K Antagonist Oral Anticoagulants (TICH-NOAC): A Multicenter, Randomized, Placebo-Controlled, Phase 2 Trial.

Journal Paper/Review - Jul 19, 2023

Polymeris Alexandros A, Karwacki Grzegorz M, Siepen Bernhard M, Schaedelin Sabine A, Tsakiris Dimitrios A, Stippich Christoph, Guzman Raphael, Nickel Christian H, Sprigg Nikola, Kägi Georg, Vehoff Jochen, Barinka Filip, Thilemann Sebastian, Maurer Marina, Wagner Benjamin, Traenka Christopher, Gensicke Henrik, De Marchis Gian Marco, Bonati Leo H, Fischer Urs, Z'Graggen Werner J, Nedeltchev Krassen, Wegener Susanne, Baumgartner Philipp, Engelter Stefan T, Seiffge David Julian, Peters Nils, Lyrer Philippe A, TICH-NOAC Investigators

Citation

Polymeris A, Karwacki G, Siepen B, Schaedelin S, Tsakiris D, Stippich C, Guzman R, Nickel C, Sprigg N, Kägi G, Vehoff J, Barinka F, Thilemann S, Maurer M, Wagner B, Traenka C, Gensicke H, De Marchis G, Bonati L, Fischer U, Z'Graggen W, Nedeltchev K, Wegener S, Baumgartner P, Engelter S, Seiffge D, Peters N, Lyrer P, TICH-NOAC Investigators. Tranexamic Acid for Intracerebral Hemorrhage in Patients on Non-Vitamin K Antagonist Oral Anticoagulants (TICH-NOAC): A Multicenter, Randomized, Placebo-Controlled, Phase 2 Trial. Stroke 2023; 54:2223-2234.

Type

Journal Paper/Review (English)

Journal

Stroke 2023; 54

Publication Date

Jul 19, 2023

Issn Electronic

1524-4628

Pages

2223-2234

Brief description/objective

Evidence-based hemostatic treatment for intracerebral hemorrhage (ICH) associated with non-vitamin K antagonist oral anticoagulants (NOACs) is lacking. Tranexamic acid (TXA) is an antifibrinolytic drug potentially limiting hematoma expansion. We aimed to assess the efficacy and safety of TXA in NOAC-ICH.