Impact of central nervous system involvement in adult patients with Philadelphia-negative acute lymphoblastic leukemia: a GRAALL-2005 study.

Publication

Impact of central nervous system involvement in adult patients with Philadelphia-negative acute lymphoblastic leukemia: a GRAALL-2005 study.

Journal Paper/Review - Mar 9, 2023

Orvain Corentin, Chantepie Sylvain, Thomas Xavier, Escofrre-Barbe Martine, Huguet Françoise, Desbrosses Yohan, Guillerm Gaelle, Uzunov Madalina, Leguay Thibaut, Barbieux Sarah, Vey Norbert, Chevallier Patrice, Malfuson Jean-Valere, Lepretre Stephane, Baumann Michael, Aykut Murat, Chaib Abdelaziz, Joris Magalie, Zerazhi Hacene, Stussi Georg, Chapiro Jacques, Berthon Celine, Bonmati Caroline, Jourdan Eric, Carp Diana, Marcais Amb Roise, Gallego-Hernanz Maria-Pilar, Vaida Iona, Bilger Karin, Villate Alban, Pasquier Florence, Chalandon Yves, Maury Sébastien, Lhéritier Véronique, Ifrah Norbert, Dombret Hervé, Boissel Nicolas, Hunault-Berger Mathilde

Citation

Orvain C, Chantepie S, Thomas X, Escofrre-Barbe M, Huguet F, Desbrosses Y, Guillerm G, Uzunov M, Leguay T, Barbieux S, Vey N, Chevallier P, Malfuson J, Lepretre S, Baumann M, Aykut M, Chaib A, Joris M, Zerazhi H, Stussi G, Chapiro J, Berthon C, Bonmati C, Jourdan E, Carp D, Marcais A, Gallego-Hernanz M, Vaida I, Bilger K, Villate A, Pasquier F, Chalandon Y, Maury S, Lhéritier V, Ifrah N, Dombret H, Boissel N, Hunault-Berger M. Impact of central nervous system involvement in adult patients with Philadelphia-negative acute lymphoblastic leukemia: a GRAALL-2005 study. Haematologica 2023

Type

Journal Paper/Review (English)

Journal

Haematologica 2023

Publication Date

Mar 9, 2023

Issn Electronic

1592-8721

Brief description/objective

Whereas the prognosis of adult patients with Philadelphia-negative acute lymphoblastic leukemia (ALL) has greatly improved since the advent of pediatric-inspired regimens, the impact of initial central nervous system (CNS) involvement has not been formerly reevaluated. We report herein the outcome of patients with initial CNS involvement included in the pediatric-inspired prospective randomized GRAALL-2005 study. Between 2006 and 2014, 784 adult patients (18-59 years old) with newly diagnosed Philadelphia-negative ALL were included of whom 55 (7%) had CNS involvement. In CNS-positive patients, overall survival was shorter (median 1.9 years vs. not reached, HR=1.8 [1.3-2.6], P.