Effect of SLCO1B1 c.521T>C polymorphism on the lipid response to statins in people living with HIV on a boosted protease inhibitor containing regimen.
Journal Paper/Review - Apr 26, 2023
Marzolini Catia, Cavassini Matthias, Braun Dominique Laurent, Hachfeld Anna, Bernasconi Enos, Calmy Alexandra, Schmid Patrick, Battegay Manuel, Elzi Luigia, Swiss HIV Cohort Study SHCS
We previously observed that some individuals on HIV boosted protease inhibitor containing regimen do not achieve their lipid targets despite elevated statin concentrations. This study evaluated whether the common single polymorphism c.521T>C in SLCO1B1, associated with reduced statin uptake in the liver, could explain this observation.