Publication
iRECIST and atypical patterns of response to immuno-oncology drugs.
Journal Paper/Review - Jun 1, 2022
Ramon-Patino Jorge Luis, Schmid Sabine, Lau Sally, Seymour Lesley, Gaudreau Pierre-Olivier, Li Janice Juan Ning, Bradbury Penelope Ann, Calvo Emiliano
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PubMed
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Journal
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Issn Electronic
Brief description/objective
With the advent of immunotherapy as one of the keystones of the treatment of our patients with cancer, a number of atypical patterns of response to these agents has been identified. These include pseudoprogression, where the tumor initially shows objective growth before decreasing in size, and hyperprogression, hypothesized to be a drug-induced acceleration of the tumor burden. Despite it being >10 years since the first immune-oncology drug was approved, neither the biology behind these paradoxical responses has been well understood, nor their incidence, identification criteria, predictive biomarkers, or clinical impact have been fully described. Immune-based Response Evaluation Criteria in Solid Tumors (iRECIST) guidelines have been published as a revision to the RECIST V.1.1 criteria for use in trials of immunotherapeutics, and the iRECIST subcommittee (of the RECIST Working Group) is working on elucidating these aspects, with data sharing a current major challenge to move forward with this unmet need in immuno-oncology.