Local administration of Mitomycin-C-Treated peripheral blood mononuclear cells (PBMCs) prolongs allograft survival in vascularized composite allotransplantation.

Publication

Local administration of Mitomycin-C-Treated peripheral blood mononuclear cells (PBMCs) prolongs allograft survival in vascularized composite allotransplantation.

Journal Paper/Review - Nov 17, 2015

Radu Christian Andreas, Kiefer Jurij, Gebhard Martha Maria, Bigdeli Amir Khosrow, Schmidt Volker, Germann Guenter, Lehnhardt Marcus, Terness Peter, Kneser Ulrich, Kremer Thomas

Citation

Radu C, Kiefer J, Gebhard M, Bigdeli A, Schmidt V, Germann G, Lehnhardt M, Terness P, Kneser U, Kremer T. Local administration of Mitomycin-C-Treated peripheral blood mononuclear cells (PBMCs) prolongs allograft survival in vascularized composite allotransplantation. Microsurgery 2015; 36:417-425.

Type

Journal Paper/Review (English)

Journal

Microsurgery 2015; 36

Publication Date

Nov 17, 2015

Issn Electronic

1098-2752

Pages

417-425

Brief description/objective

VCA offers a potential treatment for extensive tissue defects. First results of systemic administration of Mitomycin C-treated PBMCs in VCA demonstrated a significant prolongation of allograft survival. The aim of this study is to evaluate if local administration of MMC-PBMCs prolongs allograft survival in allogeneic hind limb transplantations of the rat.