Collagen-Elastin and Collagen-Glycosaminoglycan Scaffolds Promote Distinct Patterns of Matrix Maturation and Axial Vascularization in Arteriovenous Loop-Based Soft Tissue Flaps.

Publication

Collagen-Elastin and Collagen-Glycosaminoglycan Scaffolds Promote Distinct Patterns of Matrix Maturation and Axial Vascularization in Arteriovenous Loop-Based Soft Tissue Flaps.

Journal Paper/Review - Jul 1, 2017

Schmidt Volker, Wietbrock Johanna O, Leibig Nico, Gloe Torsten, Henn Dominic, Hernekamp J Frederik, Harhaus Leila, Kneser Ulrich

Citation

Schmidt V, Wietbrock J, Leibig N, Gloe T, Henn D, Hernekamp J, Harhaus L, Kneser U. Collagen-Elastin and Collagen-Glycosaminoglycan Scaffolds Promote Distinct Patterns of Matrix Maturation and Axial Vascularization in Arteriovenous Loop-Based Soft Tissue Flaps. Ann Plast Surg 2017; 79:92-100.

Type

Journal Paper/Review (English)

Journal

Ann Plast Surg 2017; 79

Publication Date

Jul 1, 2017

Issn Electronic

1536-3708

Pages

92-100

Brief description/objective

Autologous free flaps are the criterion standard for reconstructions of complex soft tissue defects; however, they are limited by donor-site morbidities. The arteriovenous (AV) loop model enables the generation of soft tissue constructs based on acellular dermal matrices with a functional microvasculature and minimal donor site morbidity. The ideal scaffold for AV loop-based tissue engineering has not been determined.