Micro-RNA-Regulated Proangiogenic Signaling in Arteriovenous Loops in Patients with Combined Vascular and Soft-Tissue Reconstructions: Revisiting the Nutrient Flap Concept.

Publication

Micro-RNA-Regulated Proangiogenic Signaling in Arteriovenous Loops in Patients with Combined Vascular and Soft-Tissue Reconstructions: Revisiting the Nutrient Flap Concept.

Journal Paper/Review - Oct 1, 2018

Henn Dominic, Abu-Halima Masood, Falkner Florian, Wermke Dominik, Meme Lilian G, Kühner Clemens, Keller Andreas, Kneser Ulrich, Meese Eckart, Schmidt Volker

Citation

Henn D, Abu-Halima M, Falkner F, Wermke D, Meme L, Kühner C, Keller A, Kneser U, Meese E, Schmidt V. Micro-RNA-Regulated Proangiogenic Signaling in Arteriovenous Loops in Patients with Combined Vascular and Soft-Tissue Reconstructions: Revisiting the Nutrient Flap Concept. Plast Reconstr Surg 2018; 142:489e-502e.

Type

Journal Paper/Review (English)

Journal

Plast Reconstr Surg 2018; 142

Publication Date

Oct 1, 2018

Issn Electronic

1529-4242

Pages

489e-502e

Brief description/objective

The placement of arteriovenous loops can enable microvascular anastomoses of free flaps when recipient vessels are scarce. In animal models, elevated fluid shear stress in arteriovenous loops promotes neoangiogenesis. Anecdotal reports in patients indicate that vein grafts used in free flap reconstructions of ischemic lower extremities are able to induce capillary formation. However, flow-stimulated angiogenesis has never been systematically investigated in humans, and it is unclear whether shear stress alters proangiogenic signaling pathways within the vascular wall of human arteriovenous loops.