Enrichment of Nanofiber Hydrogel Composite with Fractionated Fat Promotes Regenerative Macrophage Polarization and Vascularization for Soft-Tissue Engineering.

Publication

Enrichment of Nanofiber Hydrogel Composite with Fractionated Fat Promotes Regenerative Macrophage Polarization and Vascularization for Soft-Tissue Engineering.

Journal Paper/Review - Mar 1, 2022

Henn Dominic, Fischer Katharina S, Chen Kellen, Greco Autumn H, Martin Russell A, Sivaraj Dharshan, Trotsyuk Artem A, Mao Hai-Quan, Reddy Sashank K, Kneser Ulrich, Gurtner Geoffrey C, Schmidt Volker, Sacks Justin M

Citation

Henn D, Fischer K, Chen K, Greco A, Martin R, Sivaraj D, Trotsyuk A, Mao H, Reddy S, Kneser U, Gurtner G, Schmidt V, Sacks J. Enrichment of Nanofiber Hydrogel Composite with Fractionated Fat Promotes Regenerative Macrophage Polarization and Vascularization for Soft-Tissue Engineering. Plast Reconstr Surg 2022; 149:433e-444e.

Type

Journal Paper/Review (English)

Journal

Plast Reconstr Surg 2022; 149

Publication Date

Mar 1, 2022

Issn Electronic

1529-4242

Pages

433e-444e

Brief description/objective

Fractionated fat has been shown to promote dermal regeneration; however, the use of fat grafting for reconstruction of soft-tissue defects is limited because of volume loss over time. The authors have developed a novel approach for engineering of vascularized soft tissue using an injectable nanofiber hydrogel composite enriched with fractionated fat.