Prophylactic treatment of breast implants with a solution of gentamicin, vancomycin and cefazolin antibiotics for women undergoing breast reconstructive surgery: protocol for a randomised, double-blind, placebo-controlled trial (The BREAST-AB trial).

Publication

Prophylactic treatment of breast implants with a solution of gentamicin, vancomycin and cefazolin antibiotics for women undergoing breast reconstructive surgery: protocol for a randomised, double-blind, placebo-controlled trial (The BREAST-AB trial).

Journal Paper/Review - Sep 17, 2022

Hemmingsen Mathilde Nejrup, Larsen Andreas, Weltz Tim K, Ørholt Mathias, Wiberg Sebastian, Bennedsen Anne Karen, Bille Camilla, Carstensen Lena Felicia, Jensen Lisa Toft, Bredgaard Rikke, Koudahl Vibeke, Schmidt Volker, Vester-Glowinski Peter, Hölmich LisbRosenkrantz, Sørensen Søren J, Bjarnsholt Thomas, Damsgaard Tine, Herly Mikkel

Citation

Hemmingsen M, Larsen A, Weltz T, Ørholt M, Wiberg S, Bennedsen A, Bille C, Carstensen L, Jensen L, Bredgaard R, Koudahl V, Schmidt V, Vester-Glowinski P, Hölmich L, Sørensen S, Bjarnsholt T, Damsgaard T, Herly M. Prophylactic treatment of breast implants with a solution of gentamicin, vancomycin and cefazolin antibiotics for women undergoing breast reconstructive surgery: protocol for a randomised, double-blind, placebo-controlled trial (The BREAST-AB trial). BMJ Open 2022; 12:e058697.

Type

Journal Paper/Review (English)

Journal

BMJ Open 2022; 12

Publication Date

Sep 17, 2022

Issn Electronic

2044-6055

Pages

e058697

Brief description/objective

Periprosthetic infection is one of the most severe complications following implant-based breast reconstruction affecting 5%-10% of the women. Currently, many surgeons apply antibiotics locally on the breast implant to reduce the risk of postoperative infection, but no randomised, placebo-controlled trials have tested the treatment's efficacy.