Publication

Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.

Journal Paper/Review - Jan 19, 2023

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Citation
Bakker M, Kanning J, Abraham G, Martinsen A, Winsvold B, Zwart J, Bourcier R, Sawada T, Koido M, Kamatani Y, Morel S, Amouyel P, Debette S, Bijlenga P, Berrandou T, Ganesh S, Bouatia-Naji N, Jones G, Bown M, Rinkel G, Veldink J, Ruigrok Y, Hostettler I. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity. Stroke 2023
Type
Journal Paper/Review (English)
Journal
Stroke 2023
Publication Date
Jan 19, 2023
Issn Electronic
1524-4628
Brief description/objective

Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of unruptured IA and ASAH) and (2) assess its association with patient characteristics.