Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.
Journal Paper/Review - Jan 19, 2023
Bakker Mark K, Kanning Jos P, Abraham Gad, Martinsen Amy E, Winsvold Bendik S, Zwart John-Anker, Bourcier Romain, Sawada Tomonobu, Koido Masaru, Kamatani Yoichiro, Morel Sandrine, Amouyel Philippe, Debette Stephanie, Bijlenga Philippe, Berrandou Takiy, Ganesh Santhi K, Bouatia-Naji Nabila, Jones Gregory T, Bown Matthew, Rinkel Gabriel J E, Veldink Jan H, Ruigrok Ynte M, Hostettler Isabel C
Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of unruptured IA and ASAH) and (2) assess its association with patient characteristics.