Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.

Publication

Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.

Journal Paper/Review - Jan 19, 2023

Bakker Mark K, Kanning Jos P, Abraham Gad, Martinsen Amy E, Winsvold Bendik S, Zwart John-Anker, Bourcier Romain, Sawada Tomonobu, Koido Masaru, Kamatani Yoichiro, Morel Sandrine, Amouyel Philippe, Debette Stephanie, Bijlenga Philippe, Berrandou Takiy, Ganesh Santhi K, Bouatia-Naji Nabila, Jones Gregory T, Bown Matthew, Rinkel Gabriel J E, Veldink Jan H, Ruigrok Ynte M, Hostettler Isabel C

Citation

Bakker M, Kanning J, Abraham G, Martinsen A, Winsvold B, Zwart J, Bourcier R, Sawada T, Koido M, Kamatani Y, Morel S, Amouyel P, Debette S, Bijlenga P, Berrandou T, Ganesh S, Bouatia-Naji N, Jones G, Bown M, Rinkel G, Veldink J, Ruigrok Y, Hostettler I. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity. Stroke 2023

Type

Journal Paper/Review (English)

Journal

Stroke 2023

Publication Date

Jan 19, 2023

Issn Electronic

1524-4628

Brief description/objective

Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of unruptured IA and ASAH) and (2) assess its association with patient characteristics.