Excel-Based Tool for Pharmacokinetically Guided Dose Adjustment of Paclitaxel.

Publication

Excel-Based Tool for Pharmacokinetically Guided Dose Adjustment of Paclitaxel.

Journal Paper/Review - Dec 1, 2015

Kraff Stefanie, Lindauer Andreas, Joerger Markus, Salamone Salvatore J, Jaehde Ulrich

Citation

Kraff S, Lindauer A, Joerger M, Salamone S, Jaehde U. Excel-Based Tool for Pharmacokinetically Guided Dose Adjustment of Paclitaxel. Ther Drug Monit 2015; 37:725-32.

Type

Journal Paper/Review (English)

Journal

Ther Drug Monit 2015; 37

Publication Date

Dec 1, 2015

Issn Electronic

1536-3694

Pages

725-32

Brief description/objective

Neutropenia is a frequent and severe adverse event in patients receiving paclitaxel chemotherapy. The time above a paclitaxel threshold concentration of 0.05 μmol/L (Tc > 0.05 μmol/L) is a strong predictor for paclitaxel-associated neutropenia and has been proposed as a target pharmacokinetic (PK) parameter for paclitaxel therapeutic drug monitoring and dose adaptation. Up to now, individual Tc > 0.05 μmol/L values are estimated based on a published PK model of paclitaxel by using the software NONMEM. Because many clinicians are not familiar with the use of NONMEM, an Excel-based dosing tool was developed to allow calculation of paclitaxel Tc > 0.05 μmol/L and give clinicians an easy-to-use tool.