Prevalence of Transcriptionally Active HPV Infection in Tumor-Free Oropharyngeal Tissue of OPSCC-Patients.

Publication

Prevalence of Transcriptionally Active HPV Infection in Tumor-Free Oropharyngeal Tissue of OPSCC-Patients.

Journal Paper/Review - Apr 22, 2022

Guarda Vittoria, Schroeder Lea, Pawlita Michael, Ikenberg Kristian, Rupp Niels J, Jochum Wolfram, Stoeckli Sandro J, Holzinger Dana, Broglie Martina A

Citation

Guarda V, Schroeder L, Pawlita M, Ikenberg K, Rupp N, Jochum W, Stoeckli S, Holzinger D, Broglie M. Prevalence of Transcriptionally Active HPV Infection in Tumor-Free Oropharyngeal Tissue of OPSCC-Patients. Front Oncol 2022; 12:835814.

Type

Journal Paper/Review (English)

Journal

Front Oncol 2022; 12

Publication Date

Apr 22, 2022

Issn Print

2234-943X

Pages

835814

Brief description/objective

The natural history of HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is still largely unknown. Since reports of second primary tumors (SPTs) in patients with HPV-related OPSCCs are increasing, a multifocal HPV infection, hinting a «virus-induced field effect», has been hypothesized. This study aimed to investigate the HPV-prevalence in normal appearing oropharyngeal tissue in patients with OPSCCs.