Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation.

Publication

Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation.

Journal Paper/Review - May 30, 2022

Oliveri Franziska, Basler Michael, Rao Tata Nageswara, Fehling Hans Joerg, Groettrup Marcus

Citation

Oliveri F, Basler M, Rao T, Fehling H, Groettrup M. Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation. Front Immunol 2022; 13:870720.

Type

Journal Paper/Review (English)

Journal

Front Immunol 2022; 13

Publication Date

May 30, 2022

Issn Electronic

1664-3224

Pages

870720

Brief description/objective

Allergic asthma is a chronic disease and medical treatment often fails to fully control the disease in the long term, leading to a great need for new therapeutic approaches. Immunoproteasome inhibition impairs T helper cell function and is effective in many (auto-) inflammatory settings but its effect on allergic airway inflammation is unknown.