Characteristics of immune checkpoint inhibitor-induced encephalitis and comparison with HSV-1 and anti-LGI1 encephalitis: A retrospective multicentre cohort study.

Publication

Characteristics of immune checkpoint inhibitor-induced encephalitis and comparison with HSV-1 and anti-LGI1 encephalitis: A retrospective multicentre cohort study.

Journal Paper/Review - Sep 22, 2022

Müller-Jensen Leonie, Zierold Sarah, Versluis Judith M, Boehmerle Wolfgang, Huehnchen Petra, Endres Matthias, Mohr Raphael, Compter Annette, Blank Christian U, Hagenacker Tim, Meier Friedegund, Reinhardt Lydia, Gesierich Anja, Salzmann Martin, Hassel Jessica C, Ugurel Selma, Zimmer Lisa, Banks Patricia, Spain Lavinia, Soon Jennifer A, Enokida Tomohiro, Tahara Makoto, Kähler Katharina C, Seggewiss-Bernhardt Ruth, Harvey Catriona, Long Georgina V, Schöberl Florian, von Baumgarten Louisa, Hundsberger Thomas, Schlaak Max, French Lars E, Knauss Samuel, Heinzerling Lucie M

Citation

Müller-Jensen L, Zierold S, Versluis J, Boehmerle W, Huehnchen P, Endres M, Mohr R, Compter A, Blank C, Hagenacker T, Meier F, Reinhardt L, Gesierich A, Salzmann M, Hassel J, Ugurel S, Zimmer L, Banks P, Spain L, Soon J, Enokida T, Tahara M, Kähler K, Seggewiss-Bernhardt R, Harvey C, Long G, Schöberl F, von Baumgarten L, Hundsberger T, Schlaak M, French L, Knauss S, Heinzerling L. Characteristics of immune checkpoint inhibitor-induced encephalitis and comparison with HSV-1 and anti-LGI1 encephalitis: A retrospective multicentre cohort study. Eur J Cancer 2022; 175:224-235.

Type

Journal Paper/Review (English)

Journal

Eur J Cancer 2022; 175

Publication Date

Sep 22, 2022

Issn Electronic

1879-0852

Pages

224-235

Brief description/objective

Immune checkpoint inhibitor-induced encephalitis (ICI-iE) is a rare but life-threatening toxicity of immune checkpoint inhibitor treatment. We aim to identify the characteristics of ICI-iE and describe factors that discriminate it from herpes simplex virus (HSV)-1 encephalitis and anti-leucine-rich glioma-inactivated 1 (anti-LGI1) encephalitis, as two alternative entities of encephalitis.