Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera.

Publication

Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera.

Journal Paper/Review - Jun 18, 2017

Meyer Sara C, Steinmann Eva, Lehmann Thomas, Muesser Patricia, Passweg Jakob R, Skoda Radek C, Tsakiris Dimitrios A

Citation

Meyer S, Steinmann E, Lehmann T, Muesser P, Passweg J, Skoda R, Tsakiris D. Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera. Biomed Res Int 2017; 2017:9876819.

Type

Journal Paper/Review (English)

Journal

Biomed Res Int 2017; 2017

Publication Date

Jun 18, 2017

Issn Electronic

2314-6141

Pages

9876819

Brief description/objective

Myeloproliferative neoplasms (MPN) encounter thromboses due to multiple known risk factors. Heparin-induced thrombocytopenia (HIT) is a thrombotic syndrome mediated by anti-platelet factor 4 (PF4)/heparin antibodies with undetermined significance for thrombosis in MPN. We hypothesized that anti-PF4/heparin Ab might occur in MPN and promote thrombosis.