Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera.
Journal Paper/Review - Jun 18, 2017
Meyer Sara C, Steinmann Eva, Lehmann Thomas, Muesser Patricia, Passweg Jakob R, Skoda Radek C, Tsakiris Dimitrios A
Myeloproliferative neoplasms (MPN) encounter thromboses due to multiple known risk factors. Heparin-induced thrombocytopenia (HIT) is a thrombotic syndrome mediated by anti-platelet factor 4 (PF4)/heparin antibodies with undetermined significance for thrombosis in MPN. We hypothesized that anti-PF4/heparin Ab might occur in MPN and promote thrombosis.