The Activation Pattern of Drug-Reacting T Cells Has an Impact on the Clinical Picture of Hypersensitivity Reactions.

Publication

The Activation Pattern of Drug-Reacting T Cells Has an Impact on the Clinical Picture of Hypersensitivity Reactions.

Journal Paper/Review - Feb 21, 2022

Wuillemin Natascha, Ballmer-Weber Barbara, Schlapbach Christoph, Jörg Lukas, Yerly Daniel

Citation

Wuillemin N, Ballmer-Weber B, Schlapbach C, Jörg L, Yerly D. The Activation Pattern of Drug-Reacting T Cells Has an Impact on the Clinical Picture of Hypersensitivity Reactions. Front Allergy 2022; 3:804605.

Type

Journal Paper/Review (English)

Journal

Front Allergy 2022; 3

Publication Date

Feb 21, 2022

Issn Electronic

2673-6101

Pages

804605

Brief description/objective

β-lactam antibiotics cause drug hypersensitivity reactions (DHR) with various clinical pictures from minor affections like maculopapular exanthema (MPE) and urticaria to severe cutaneous adverse reactions and anaphylaxis. Currently, two different reactivity patterns have been shown to initiate an immune reaction by activating T cells-the hapten concept and the pharmacological interaction with immune receptor (p-i) concept.