The impact of pre-transplant donor specific antibodies on the outcome of kidney transplantation - Data from the Swiss transplant cohort study. - Publication

Publication

The impact of pre-transplant donor specific antibodies on the outcome of kidney transplantation - Data from the Swiss transplant cohort study.

Journal Paper/Review - Sep 21, 2022

Frischknecht Lukas, Deng Yun, Wehmeier Caroline, de Rougemont Olivier, Villard Jean, Ferrari-Lacraz Sylvie, Golshayan Déla, Gannagé Monique, Binet Isabelle, Wirthmueller Urs, Sidler Daniel, Schachtner Thomas, Schaub Stefan, Nilsson Jakob, Swiss Transplant Cohort Study

Citation

Frischknecht L, Deng Y, Wehmeier C, de Rougemont O, Villard J, Ferrari-Lacraz S, Golshayan D, Gannagé M, Binet I, Wirthmueller U, Sidler D, Schachtner T, Schaub S, Nilsson J, Swiss Transplant Cohort Study. The impact of pre-transplant donor specific antibodies on the outcome of kidney transplantation - Data from the Swiss transplant cohort study. Front Immunol 2022; 13:1005790.

Type

Journal Paper/Review (English)

Journal

Front Immunol 2022; 13

Publication Date

Sep 21, 2022

Issn Electronic

1664-3224

Pages

1005790

Brief description/objective

Pre-transplant donor specific antibodies (DSA), directed at non-self human leukocyte antigen (HLA) protein variants present in the donor organ, have been associated with worse outcomes in kidney transplantation. The impact of the mean fluorescence intensity (MFI) and the target HLA antigen of the detected DSA has, however, not been conclusively studied in a large cohort with a complete virtual cross-match (vXM).