Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression.

Publication

Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression.

Journal Paper/Review - Jan 13, 2022

Stallhofer Johannes, Veith Lisa, Diegelmann Julia, Probst Philipp, Brand Stephan, Schnitzler Fabian, Olszak Torsten, Török Helga P, Mayerle Julia, Stallmach Andreas, Beigel Florian

Citation

Stallhofer J, Veith L, Diegelmann J, Probst P, Brand S, Schnitzler F, Olszak T, Török H, Mayerle J, Stallmach A, Beigel F. Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression. Clin Transl Gastroenterol 2022; 13:e00450.

Type

Journal Paper/Review (English)

Journal

Clin Transl Gastroenterol 2022; 13

Publication Date

Jan 13, 2022

Issn Electronic

2155-384X

Pages

e00450

Brief description/objective

Iron deficiency and vitamin D deficiency are common comorbidities in inflammatory bowel disease (IBD). Accumulating evidence indicates that active 1,25-dihydroxyvitamin D (1,25(OH)D) may enhance iron absorption by suppressing hepcidin. We investigated the influence of vitamin D on iron metabolism in patients with IBD and on the expression of genes facilitating intestinal epithelial iron absorption.