Levetiracetam versus Phenobarbital for Neonatal Seizures: A Retrospective Cohort Study.
Journal Paper/Review - Oct 22, 2022
Bättig Linda, Dünner Corinne, Cserpan Dorottya, Rüegger Andrea, Hagmann Cornelia, Schmitt Bernhard, Pisani Francesco, Ramantani Georgia
Although phenobarbital (PB) is commonly used as a first-line antiseizure medication (ASM) for neonatal seizures, in 2015 we chose to replace it with levetiracetam (LEV), a third-generation ASM. Here, we compared the safety and efficacy of LEV and PB as first-line ASM, considering the years before and after modifying our treatment protocol.