Maximal surgical tumour load reduction in immune-checkpoint inhibitor naïve patients with melanoma brain metastases correlates with prolonged survival.

Publication

Maximal surgical tumour load reduction in immune-checkpoint inhibitor naïve patients with melanoma brain metastases correlates with prolonged survival.

Journal Paper/Review - Sep 17, 2022

Voglis Stefanos, Schaller Valentina, Müller Timothy, Gönel Meltem, Winklhofer Sebastian, Mangana Joana, Dummer Reinhard, Serra Carlo, Weller Michael, Regli Luca, Le Rhun Emilie, Neidert Marian C

Citation

Voglis S, Schaller V, Müller T, Gönel M, Winklhofer S, Mangana J, Dummer R, Serra C, Weller M, Regli L, Le Rhun E, Neidert M. Maximal surgical tumour load reduction in immune-checkpoint inhibitor naïve patients with melanoma brain metastases correlates with prolonged survival. Eur J Cancer 2022; 175:158-168.

Type

Journal Paper/Review (English)

Journal

Eur J Cancer 2022; 175

Publication Date

Sep 17, 2022

Issn Electronic

1879-0852

Pages

158-168

Brief description/objective

Recent therapeutic advances in metastatic melanoma have led to improved overall survival (OS) rates, with consequently an increased incidence of brain metastases (BM). The role of BM resection in the era of targeted and immunotherapy should be reassessed. In the current study we analysed the role of residual intracranial tumour load in a cohort of melanoma BM patients.