Mutant driving the Warburg Effect in Mantle Cell lymphoma.
Journal Paper/Review - Oct 3, 2022
Kliebhan Johannes, Besse Andrej, Kampa-Schittenhelm Kerstin M, Schittenhelm Marcus, Driessen Christoph
The p53 mutation R273H in tumor cells leads to increased glucose uptake, lactic acidosis, and accelerated tumor growth, as was previously shown in mice. We here present a patient with mantle cell lymphoma harboring this p53_R273H mutation, whose clinical course is characterized by severe lactic acidosis, hypoglycemia, and aggressive disease.