Publication

A life-threatening abscess in a patient treated with a tumour necrosis factor-alpha antagonist: a case report

Journal Paper/Review - Aug 1, 2009

Units
PubMed

Citation
Cadosch D, Neukom L, Gautschi O, Zellweger R. A life-threatening abscess in a patient treated with a tumour necrosis factor-alpha antagonist: a case report. Journal of orthopaedic surgery (Hong Kong) 2009; 17:227-30.
Type
Journal Paper/Review (English)
Journal
Journal of orthopaedic surgery (Hong Kong) 2009; 17
Publication Date
Aug 1, 2009
Issn Print
1022-5536
Pages
227-30
Brief description/objective

A 25-year-old man with a 3-year history of ankylosing spondylitis presented with a sudden onset of pain in his left thigh. His ankylosing spondylitis had been treated for 2 years with the tumour necrosis factor-alpha (TNF-alpha) antagonist infliximab. The initial diagnosis was a muscular tear, and non-steroidal anti-inflammatory drugs were prescribed. 40 days later, the patient had tender swelling with warmth and light redness on his left thigh. His knee function had decreased markedly. His C-reactive protein level was 320 mg/l and white cell count was 30.4 x10(9)/l, indicating severe infection. Magnetic resonance imaging revealed a loculated fluid collection in the quadriceps musculature measuring 30 cm. Hyperintensity seen on T1-weighted images was suggestive of infection. The infliximab therapy was stopped and repeated debridement and drainage performed, with about 2.5 litres of pus evacuated. Flucloxacillin was administered for 2 weeks. The wound was closed 9 days later. The patient was discharged 20 days after surgery. An alternative immunosuppressive therapy--abatacept--was introduced. At the 18-month follow-up, the patient reported only light discomfort in the thigh during exercise, with a mildly impaired range of knee movement. No infectious complications recurred.