Publication

Analysis of patients with rheumatoid arthritis and higher radiographic progression: association of very high radiographic progression but not of intermediately high worsening of patient-related outcomes

Journal Paper/Review - May 5, 2021

Units
Keywords
PubMed
Doi
Link
Contact

Citation
Thalmann R, von Kempis J, Zgraggen A, Graf N, Schiff M, Sokka T, Dietrich T, Schulze-Koops H, Mueller R. Analysis of patients with rheumatoid arthritis and higher radiographic progression: association of very high radiographic progression but not of intermediately high worsening of patient-related outcomes. Clin Exp Rheumatol 2021
Project
Type
Journal Paper/Review (English)
Journal
Clin Exp Rheumatol 2021
Publication Date
May 5, 2021
Issn Print
0392-856X
Issn Electronic
Pages
Publisher
Brief description/objective

OBJECTIVES
To analyse rheumatoid arthritis (RA)-patients depending on their individual peak radiographic progression.

METHODS
We selected for the individual peak radiographic progression (Δ Ratingen scores/time) in patients of the Swiss registry SCQM. The baseline disease characteristics were compared using standard descriptive statistics. The change of DAS 28 (disease activity sore) and HAQ-DI (Health Assessment Questionnaire Disability Index) before and after peak progression was analysed with Wilcoxon signed rank tests.

RESULTS
Of the 4,033 patients in the analysis, 3,049 patients had a peak radiographic progression rate between 0 and ≤10 in the Ratingen score per year, 773 between 10 and ≤20, 150 between 20 and ≤30, and 61 of >30 (defining groups A-D). Rheumatoid factor was more frequent in patient groups with a higher peak radiographic progression (71.1%, 79.2%, 85.3%, 88.5%, groups A-D). Peak radiographic progression at a rate >20/year (groups C-D) was not detected after December 2012. When the rate of radiographic progression before and after peak progression was analysed, it was significantly lower. The DAS 28 was significantly higher in all patient groups before peak progression and lower thereafter (p<0.001). Average HAQ-DI scores increased after peak radiographic progression in group D (p=0.005) whereas it was stable or even decreased among the patients of the other patient groups.

CONCLUSIONS
These data show that the highest radiographic progression rates are rare and get less frequent over the last years. Higher disease activity precedes radiographic peak progression. Only the highest individual peak (change of Ratingen score >30/year) radiographic progression was followed by an increase of HAQ-DI scores.