Maternal outcomes and risk factors for COVID-19 severity among pregnant women

Publication

Maternal outcomes and risk factors for COVID-19 severity among pregnant women

Journal Paper/Review - Jul 6, 2021

Giannoni Eric, Lopez-Giron Maria Camila, Burgos-Luna Juan Manuel, Escobar-Vidarte Maria Fernanda, Hecher Kurt, Tallarek Ann-Christin, Hadar Eran, Haratz Karina Krajden, Amikam Uri, Malinger Gustavo, Maymon Ron, Yogev Yariv, Schäffer Leonhard, Toussaint Arnaud, Rossier Marie-Claude, Calvache Albaro José Nieto, Derouich Mohamed, Granado Cristina, Monod Cécile, Mueller Doris, Hoesli Irene, Bassler Dirk, Heldstab Sandra, Kölble Nicole Ochsenbein, Sentilhes Loïc, Charvet Melissa, Deprest Jan, Richter Jute, Van der Veeken Lennart, Eggel-Hort Béatrice, Plantefeve Gaetan, De Sa Renato Augusto Moreira, Grawe Claudia, Sedille Lucie, Papadia Andrea, Brugger Romina Capoccia, Weber Brigitte, Fischer Tina, Kahlert Christian, Saines Karin Nielsen, Cambou Mary, Kanellos Panagiotis, Chen Xiang, Yin Mingzhu, Haessig Annina, Ackermann Sandrine, Baud David, Giral Marylene, Brochut Anne-Claude Muller, Aebi-Popp Karoline, Radan Anda-Petronela, Raio Luigi, Surbek Daniel, Böckenhoff Paul, Strizek Brigitte, Kaufmann Martin, Bloch Andrea, Boulvain Michel, Johann Silke, Heldstab Sandra Andrea, Bernasconi Monya Todesco, Grant Gaston, Feki Anis, Panchaud Alice, Rozenberg Patrick, Vouga Manon, Castillo Karen, Solsona Eduard Gratacos, Trigo Lucas, Cleary Brian, Geary Michael, Bartels Helena, Al-Kharouf Feras, Malone Fergal, Higgins Mary, Keating Niamh, Knowles Susan, Poncelet Christophe, Ribeiro-do-Valle Carolina Carvalho, Surita Fernanda, Hawkins-Villarreal Ameth, Goncé Anna, Favre Guillaume, Martinez-Perez Oscar, Pomar Leo, Acebal Laura Forcen, Abascal-Saiz Alejandra, Hernandez Maria Rosa Vila, Hcini Najeh, Lambert Véronique, Carles Gabriel, Sichitiu Joanna, Salomon Laurent, Stirnemann Julien, Ville Yves, de Tejada Begoña Martinez, Dantas-Silva Amanda, Borrelli Carolina, Subtil Damien, Bohrer Betania, Da Rocha Oppermann Maria Lucia, Wender Maria Celeste Osorio, Schuler-Faccini Lavinia, Sanseverino Maria Teresa Vieira, Giugliani Camila, Friedrich Luciana, Scherer Mariana Horn, Mottet Nicolas, Ducarme Guillaume, Pelerin Helene, Moreau Chloe, Breton Bénédicte, Garabedian Charles, Martins Inês, Luz Adriana Gomes, Fuenzalida Javiera, Carvajal Jorge, Canales Manuel Guerra, Hernandez Olivia, Grechukhina Olga, Ko Albert I, Reddy Uma, Figueiredo Rita, Moucho Marina, Pinto Pedro Viana, De Luca Carmen, De Santis Marco, de Campos Diogo Ayres, Quibel Thibaud

Citation

Giannoni E, Lopez-Giron M, Burgos-Luna J, Escobar-Vidarte M, Hecher K, Tallarek A, Hadar E, Haratz K, Amikam U, Malinger G, Maymon R, Yogev Y, Schäffer L, Toussaint A, Rossier M, Calvache A, Derouich M, Granado C, Monod C, Mueller D, Hoesli I, Bassler D, Heldstab S, Kölble N, Sentilhes L, Charvet M, Deprest J, Richter J, Van der Veeken L, Eggel-Hort B, Plantefeve G, De Sa R, Grawe C, Sedille L, Papadia A, Brugger R, Weber B, Fischer T, Kahlert C, Saines K, Cambou M, Kanellos P, Chen X, Yin M, Haessig A, Ackermann S, Baud D, Giral M, Brochut A, Aebi-Popp K, Radan A, Raio L, Surbek D, Böckenhoff P, Strizek B, Kaufmann M, Bloch A, Boulvain M, Johann S, Heldstab S, Bernasconi M, Grant G, Feki A, Panchaud A, Rozenberg P, Vouga M, Castillo K, Solsona E, Trigo L, Cleary B, Geary M, Bartels H, Al-Kharouf F, Malone F, Higgins M, Keating N, Knowles S, Poncelet C, Ribeiro-do-Valle C, Surita F, Hawkins-Villarreal A, Goncé A, Favre G, Martinez-Perez O, Pomar L, Acebal L, Abascal-Saiz A, Hernandez M, Hcini N, Lambert V, Carles G, Sichitiu J, Salomon L, Stirnemann J, Ville Y, de Tejada B, Dantas-Silva A, Borrelli C, Subtil D, Bohrer B, Da Rocha Oppermann M, Wender M, Schuler-Faccini L, Sanseverino M, Giugliani C, Friedrich L, Scherer M, Mottet N, Ducarme G, Pelerin H, Moreau C, Breton B, Garabedian C, Martins I, Luz A, Fuenzalida J, Carvajal J, Canales M, Hernandez O, Grechukhina O, Ko A, Reddy U, Figueiredo R, Moucho M, Pinto P, De Luca C, De Santis M, de Campos D, Quibel T. Maternal outcomes and risk factors for COVID-19 severity among pregnant women. Sci Rep 2021; 11:13898.

Type

Journal Paper/Review (English)

Journal

Sci Rep 2021; 11

Publication Date

Jul 6, 2021

Issn Electronic

2045-2322

Pages

13898

Brief description/objective

Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant women with severe coronavirus disease 19 (cases) to pregnant women with a milder form (controls) enrolled in the COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, obstetrical and immediate neonatal outcomes were assessed. A total of 926 pregnant women with a positive test for SARS-CoV-2 were included, among which 92 (9.9%) presented with severe COVID-19 disease. Risk factors for severe maternal outcomes were pulmonary comorbidities [aOR 4.3, 95% CI 1.9-9.5], hypertensive disorders [aOR 2.7, 95% CI 1.0-7.0] and diabetes [aOR2.2, 95% CI 1.1-4.5]. Pregnant women with severe maternal outcomes were at higher risk of caesarean section [70.7% (n = 53/75)], preterm delivery [62.7% (n = 32/51)] and newborns requiring admission to the neonatal intensive care unit [41.3% (n = 31/75)]. In this study, several risk factors for developing severe complications of SARS-CoV-2 infection among pregnant women were identified including pulmonary comorbidities, hypertensive disorders and diabetes. Obstetrical and neonatal outcomes appear to be influenced by the severity of maternal disease.