International multicentre validation of the arteriovenous malformation-related intracerebral haemorrhage (AVICH) score

Publication

International multicentre validation of the arteriovenous malformation-related intracerebral haemorrhage (AVICH) score

Journal Paper/Review - Oct 6, 2017

Neidert Marian Christoph, Schackert Gabriele, Wanet Thomas, Gläsker Sven, Griessenauer Christoph J, Ogilvy Christopher S, Kneist Andreas, Sure Ulrich, Seifert Burkhardt, Regli Luca, Bozinov Oliver, Podlesek Dino, Hayase Makoto, Lawton Michael T, Kim Louis J, Nerva John D, Kurisu Kaoru, Ikawa Fusao, Konczalla Juergen, Dinc Nazife, Seifert Volker, Habdank-Kolaczkowski Julian, Hatano Taketo, Burkhardt Jan-Karl

Citation

Neidert M, Schackert G, Wanet T, Gläsker S, Griessenauer C, Ogilvy C, Kneist A, Sure U, Seifert B, Regli L, Bozinov O, Podlesek D, Hayase M, Lawton M, Kim L, Nerva J, Kurisu K, Ikawa F, Konczalla J, Dinc N, Seifert V, Habdank-Kolaczkowski J, Hatano T, Burkhardt J. International multicentre validation of the arteriovenous malformation-related intracerebral haemorrhage (AVICH) score. J Neurol Neurosurg Psychiatry 2017; 89:1163-1166.

Type

Journal Paper/Review (English)

Journal

J Neurol Neurosurg Psychiatry 2017; 89

Publication Date

Oct 6, 2017

Issn Electronic

1468-330X

Pages

1163-1166

Brief description/objective

OBJECTIVE
The recently published arteriovenous malformation-related intracerebral haemorrhage (AVICH) score showed better outcome prediction for patients with arteriovenous malformation (AVM)-related intracerebral haemorrhage (ICH) than other AVM or ICH scores. Here we present the results of a multicentre, external validation of the AVICH score.

METHODS
All participating centres (n=11) provided anonymous data on 325 patients to form the Spetzler-Martin (SM) grade, the supplemented SM (sSM) grade, the ICH score and the AVICH score. Modified Rankin score (mRS) at last follow-up (mean 25.6 months) was dichotomized into favourable (mRS 0-2, n=210) and unfavourable (mRS 3-6;n=115). Univariate and AUROC analyses were performed to validate the AVICH score.

RESULTS
Except nidus structure and AVM size, all single parameters forming the SM, sSM, ICH and AVICH score and the scores itself were significantly different between both outcome groups in the univariate analysis. The AVICH score was confirmed to be the highest predictive outcome score with an AUROC of 0.765 compared with 0.705 for the ICH score and 0.682 for the sSM grade.

CONCLUSION
The multicentre-validated AVICH score predicts clinical outcome superior to pre-existing scores. We suggest the routine use of this score for future clinical outcome prediction and in clinical research.

TRIAL REGISTRATION NUMBER
NCT02920645.