Publication

Transient Subfoveal Fluid and Visual Loss after Ocriplasmin

Journal Paper/Review - Apr 26, 2016

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Citation
Tschuppert S, Gerding H. Transient Subfoveal Fluid and Visual Loss after Ocriplasmin. Klin Monbl Augenheilkd 2016; 233:453-5.
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Type
Journal Paper/Review (English)
Journal
Klin Monbl Augenheilkd 2016; 233
Publication Date
Apr 26, 2016
Issn Print
Issn Electronic
1439-3999
Pages
453-5
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Brief description/objective

BACKGROUND
Intravitreal injection of ocriplasmin for the enzymatic resolution of vitreomacular traction was approved for the EU in 2013. We wish to report our clinical findings and adverse effects that were not observed in the registration trial.

THERAPY AND OUTCOME
In 5 of our first 12 consecutive cases, resolution of the vitreomacular traction occurred after injecting ocriplasmin. 9 of the 12 patients developed subfoveal fluid, manifest at day 3 post-intervention; this was completely re-absorbed by 6 weeks in 8 of 9 eyes. All 9 cases with subretinal fluid exhibited a significant reduction in mean visual acuity at the first visit, of 0.33 LogMAR (p = 0.008, Wilcoxon signed rank test). After regression of the subretinal fluid, visual acuity returned to the baseline value.

CONCLUSIONS
In the light of the documented adverse effects of the registration trial, the relatively high rate of subfoveal fluid after injecting ocriplasmin was surprising. Possible causes include enzymatic lysis of the matrix between the outer segments of the photoreceptors and the microvilli of the RPE-cells, or barrier disturbances in the RPE through lysis of the zonulae occludentes.