Projects
Search from 1147 projects:
221 Project(s)
SAKK 17/18 Origin
Mar 5, 2021A significant number of patients with malignant pleural mesothelioma (MPM) and non-small cell lung cancer (NSCLC) are not cured with available treatments and will eventually relapse. After relapse treatment options are limited. Preclinical in vitro s...
Clinical Studies - Mar 5, 2021 - Dec 12, 2024
Ongoing
Project leader: Jörger Markus
Atezolizumab in combination with Bevacizumab and Chemotherapy versus Bevacizumab and Chemotherapy in recurrent ovarian cancer- a randomized Phase III trial An ENGOT Trial
Mar 4, 2021This study will evaluate the efficacy and safety of atezolizumab plus bevacizumab and chemotherapy compared with placebo plus bevacizumab and chemotherapy in patients with recurrent ovarian-, fallopian tube, or primary peritoneal cancer with 1st or 2...
Clinical Studies - Mar 4, 2021 - Dec 24, 2025
Ongoing
Project leader: Hasler-Strub Ursula
CardioOnco - Diagnosing Preclinical Cardiac Dysfunction in Adult Childhood Cancer Survivors ‒ The CardioOnco study
Mar 1, 2021We aim to: 1. Assess preclinical cardiac dysfunction longitudinally using 2-dimensional (2D) and 3-dimensional (3D) conventional and 2D speckle tracking echocardiography. 2. Assess cardiopulmonary fitness using cardiopulmonary exercise testing. 3....
Clinical Studies - Mar 1, 2021 - Dec 31, 2030
Ongoing
Project leader: Scheler Eva
Members: Schneider Irene
A Phase II, Open-Label, Multicenter Study Evaluating The Safety And Efficacy Of Neoadjuvant And Adjuvant Tiragolumab Plus Atezolizumab, With Or Without Platinum-Based Chemotherapy, In Patients With Previously Untreated Locally Advanced Resectable Stage II, IIa, Or Select IIIb Non-Small Cell Lung Cancer
Feb 12, 2021Das Ziel dieser Studie ist es die Wirkungen, ob positiv oder negativ, von Tecentriq (Atezolizumab) und Tiragolumab mit oder ohne Chemotherapie bei Patienten, deren Lungenkrebs operiert werden kann, zu beurteilen. Es soll herausgefunden werden, ob und...
Clinical Studies - Feb 12, 2021 - Dec 31, 2026
Ongoing
Project leader: Fischer Stefanie
Members: Sennhauser Andrina, Quinter Janine
HIT-Studie
Feb 1, 2021Targeted correction of plasma sodium levels in hospitalized patients with hyponatremia: a randomized, controlled, parallel-group trial with blinded outcome assessment
Clinical Studies - Feb 1, 2021 - Dec 31, 2025
Ongoing
Project leader: Bilz Stefan
Members: Bontognali Martina, Räss Andrea, Rothlin Silvia, Grillmayr Victoria
I6T-MC-AMAP
Jan 29, 2021A Phase 3, Multicenter, Open-Label Extension Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Patients with Moderately to Severely Active Ulcerative Colitis LUCENT 3
Clinical Studies - Jan 29, 2021 - Dec 1, 2024
Ongoing
Project leader: Brand Stephan
Members: Krieger-Grübel Claudia, Smolders Jolijn
ESSENCE
Jan 1, 2021
Clinical Studies - Jan 1, 2021 - Dec 31, 2026
Ongoing
Project leader: Bilz Stefan
Clinical evaluation of a standard treatment algorithm for midshaft clavicle fractures
Jan 1, 2021The aim of this research project is to evaluate the evidence-based treatment standard for patients with midshaft clavicle fractures using an algorithmic approach in a Swiss multi-centre, prospective data collection. This algorithm includes not only t...
Register - Jan 1, 2021 - Dec 31, 2025
Ongoing
Project leader: Spross Christian
Members: Jost Bernhard, Zdravkovic Vilijam, Schöfl Thomas, Farei-Campagna Jan M
Diagnostic role of the "white test" with lipidic solution in the early intraoperative identification of open bile ducts for the prevention of bile leakage after liver resection - A randomized controlled multicentric superiority trial.
Jan 1, 2021Bile leakage (BL) is the most frequent complication after liver resection leading to the need of interventional drainage, ERCP or even reoperation. Strategies leading to a reduction of the rate of this complication are valuable. SMOFlipid 20% is a fa...
Clinical Studies - Jan 1, 2021 - Dec 31, 2024
Ongoing
Project leader: Tarantino Ignazio
Swiss Soliris® and Ultomiris® Reimbursement Registry SSURR: An observational registry for capturing data of patients suffering from paroxysmal nocturnal hemoglobinuria (PNH) who are treated with Soliris® (eculizumab) or Ultomiris® (ravulizumab)
Jan 1, 2021
Clinical Studies - Jan 1, 2021 - Dec 31, 2030
Ongoing
Project leader: Silzle Tobias
Members: Demmer-Steingruber Ruth, Müller Fiona
SILENT 2
Dec 4, 2020Incidence of Silent Atrial Fibrillation in Patients With Clinically Silent Brain Ischemic Lesions Arterial Fibrillation (AF) is well-recognized as a cause for cryptogenic Acute Ischemic Stroke (AIS) and is associated with Silent Brain Infarction...
Clinical Studies - Dec 4, 2020 - Dec 4, 2024
Ongoing
Project leader: Ammann Peter, Kägi Georg
Members: Brenner Roman, Vetsch Susanne, Schneider Irene
XLH-Register
Dec 1, 2020An international, multicenter, prospective, non-interventional registry for patients with X-linked hypophosphatemia (XLH)
Clinical Studies - Dec 1, 2020 - Dec 31, 2030
Ongoing
Project leader: Bilz Stefan
Members: Räss Andrea, Grillmayr Victoria
BMS CA209-914 (Checkmate 914)A Phase 3 Randomized, Double-Blind Study of Nivolumab Monotherapy
Oct 29, 2020The current standard treatment for early stage (l-lll) renal cell cancer (RCC) is surgery. While the prognosis of stage I tumors is excellent, stage II and particularly stage III have a high risk of relapse and represent a high unmet medical need. Th...
Clinical Studies - Oct 29, 2020 - Sep 30, 2030
Ongoing
Project leader: Rothermundt Christian
Intratumoral injection of IP-001 following thermal ablation in patients with advanced solid tumors. A multicenter phase Ib/IIa trial with expansion cohorts in melanoma and soft tissue sarcoma patients
Oct 7, 2020Diese Studie untersucht die Sicherheit und erste Wirksamkeit einer immunstimulierenden intratumoralen Laser-Wärmetherapie in Kombination mit dem Studienmedikament IP-001, welches in den Tumor injiziert wird. Alle Patienten in dieser Studie erhalten d...
Clinical Studies - Oct 7, 2020 - Dec 31, 2024
Ongoing
Project leader: Jörger Markus
Members: Wittwer Yvonne, Quinter Janine
SwissSCAD
Oct 1, 2020The primary aim is to gather observational data from consecutive SCAD patients in Switzerland, in order to establish a National Swiss Registry (SwissSCAD). SCAD is a poorly understood condition, affecting young patients and is associated with major...
Clinical Studies - Oct 1, 2020 - Dec 31, 2030
Ongoing
Project leader: Rickli Hans
Members: Schneider Irene
SAKK 23/18 Vision I
Aug 11, 2020Neoadjuvant chemotherapy (NAC), initially indicated to downstage tumors to achieve the option of breast conserv-ing surgery, has lately become common practice in the primary treatment of breast cancer. The use of modern NAC regimens lead to a complet...
Clinical Studies - Aug 11, 2020 - Dec 18, 2024
Ongoing
SAKK 23/18 Vision I
Aug 11, 2020Neoadjuvant chemotherapy (NAC), initially indicated to downstage tumors to achieve the option of breast conserv-ing surgery, has lately become common practice in the primary treatment of breast cancer. The use of modern NAC regimens lead to a complet...
Clinical Studies - Aug 11, 2020 - Dec 18, 2024
Ongoing
Vacuum assisted biopsy Immediately before Surgery as an Intra- or pre-Operative surrogate for patient response to Neoadjuvant chemotherapy for breast cancer (VISION I) A multicenter prospective feasibility trial
Aug 11, 2020Manche Patientinnen und Patienten mit Brustkrebs erhalten vor der Tumoroperation eine Chemotherapie, um den Tumor zu verkleinern. Manchmal wirkt diese Chemotherapie so gut, dass der Tumor nach der Chemotherapie mit bildgebenden Verfahren nicht mehr n...
Clinical Studies - Aug 11, 2020 - Dec 31, 2024
Ongoing
Project leader: Strub Christine
Members: Sennhauser Andrina, Quinter Janine
PH-L19IL2TNFNMSC-04/19 A phase II study of intratumoral administration of L19IL2/L19TNF in non-melanoma skin cancer patients with presence of injectable lesions
Aug 2, 2020
Clinical Studies - Aug 2, 2020 - Jan 25, 2030
Ongoing
Project leader: Flatz Lukas
ESSENCE Study
Aug 1, 2020
Clinical Studies - Aug 1, 2020 - Dec 31, 2029
Ongoing
Project leader: Bilz Stefan
Members: Semela David, Räss Andrea, Stillhard Roman