Dr. med. Aurelius Omlin
A PHASE II, MULTICENTRE, OPEN-LABEL STUDY OF CABOZANTINIB AS 2ND LINE TREATMENT IN SUBJECTS WITH UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC RENAL CELL CARCINOMA WITH A CLEAR-CELL COMPONENT WHO PROGRESSED AFTER 1ST LINE TREATMENT WITH CHECKPOINT INHIBITORS
Jul 17, 2020Multizentrische Studie bei Patienten mit metastasiertem Nierenzellkarzinom nach Progredienz unter einer Erstli-nientherapie mit ICI/ICI oder ICI/TKI Kombination zur Eva-luation der Wirksamkeit und Verträglichkeit des Tyrosin-kinase Inhibitors Cabozan...
Clinical Studies - Jul 17, 2020 - Jul 17, 2022
Automatically Closed
Project leader: Rothermundt Christian
Members: Aeppli Stefanie, Fischer Stefanie, Omlin Aurelius
A Phase 3, Randomized, Double-blind Trial of Pembrolizumab (MK3475) Plus Enzalutamide Plus ADT Versus Placebo Plus Enzalutamide Plus ADT in Participants With Metastatic HormoneSensitive Prostate Cancer (mHSPC) (KEYNOTE-991)
Mar 3, 2020While many men diagnosed with locally confined disease may be treated definitively with radiation or surgery, ap-proximately 30% of men have recurrent disease and go on to develop metastatic prostate cancer. In addition, 5% to 30% of men with prostat...
Clinical Studies - Mar 3, 2020 - Mar 10, 2030
Ongoing
Project leader: Omlin Aurelius
Members: Rothermundt Christian, Aeppli Stefanie
Peace-4
Apr 26, 2019Prostate cancer is the most frequent cancer in Western countries and castrate- resistant prostate cancer (CRPC) is its lethal form. Survival for CRPC patients with metastases now encompasses 30 months, while that for patients without metastases is ab...
Clinical Studies - Apr 26, 2019 - May 6, 2027
Ongoing
Project leader: Omlin Aurelius
Phase II Trial of Pembrolizumab (MK-3475) in Subjects with Metastatic Castration-Resistant Prostate Cancer (mCRPC) Previously Treated with Chemotherapy (KEYNOTE-199) / MK-3475-199 Pembro Prostata
Jul 27, 2016This is a nonrandomized, multinational, open-label trial of pembrolizumab (MK-3475) in subjects with metastatic cas-tration-resistant prostate cancer (mCRPC) previously treated with docetaxel-based chemotherapy. The trial will be conducted in conform...
Clinical Studies - Jul 27, 2016 - Jun 30, 2019
Automatically Closed
Project leader: Omlin Aurelius
An Open Label Biomarker Driven Phase II Clinical Trial of Abiraterone Acetate (AA) Re-Challenge in Patients with Metastatic Castration-Resistant Prostate Cancer and Prior Response to AA (Abi-RE)
Jun 12, 2016Clinical Trial with an IMP, risk category B according to HRA. Abiraterone acetate (AA) is a standard treatment option both in chemotherapy naïve and docetaxel pre-treated men with metastatic castrate-resistant prostate cancer (CRPC). With the approva...
Clinical Studies - Jun 12, 2016 - Dec 31, 2017
Automatically Closed
Project leader: Omlin Aurelius
Single arm open label phase II pilot study of carboplatin in patients with metastatic castration-resistant prostate cancer (CRPC) and PTEN-loss and/or DNA repair defects. PRO-PLAT
Feb 17, 2016Clinical studies in unselected prostate cancer patients strongly support the hypothesis that platinums have anti-tumour activity in some patients with CRPC. For patients progressing after docetaxel based chemotherapy and a novel androgen receptor tar...
Clinical Studies - Feb 17, 2016 - Jan 1, 2019
Automatically Closed
Project leader: Omlin Aurelius
An open-label, multicohort, phase II study of MPDL3280A in advanced solid tumors
Jul 8, 2015MO29518 ist eine offene, multizentrische, multinationale Phase-II-Studie mit 10 Kohorten, welche MPDL3280A (Anti-PD-L1 Antikörper) bei Patienten mit fortgeschrittenen soliden Tumoren untersucht (Gebärmutterhalskrebs, Nasen-Rachenkrebs, spezielle Art...
Clinical Studies - Jul 8, 2015 - Jul 31, 2019
Automatically Closed
Project leader: Gillessen Sommer Silke
Members: Schmid Sabine, Fischer Stefanie, Rothermundt Christian, Templeton Arnoud, Omlin Aurelius, Desax Marie-Claire, Früh Martin, Weisshaupt Christian
A phase III, open-label, multicenter, randomized study to investigate the efficacy and safety of MPDL3280A (ANTI−PD-L1 ANTIBODY) compared with chemotherapy in patients with locally advanced or metastatic urothelial bladder cancer after failure with platinum-containing chem-otherapy. GO29294
Apr 2, 2015Dies ist eine globale, multizentrische, offene, zweiarmige, randomisierte, kontrollierte Phase-III Studie zur Beurteilung der Wirksamkeit und Sicherheit von MPDL3280A im Ver-gleich mit Chemotherapie bei Patienten mit lokal fortge-schrittenem oder met...
Clinical Studies - Apr 2, 2015 - Dec 1, 2016
Automatically Closed
Project leader: Gillessen Sommer Silke
Members: Templeton Arnoud, Rothermundt Christian, Omlin Aurelius, Desax Marie-Claire
SINGLE ARM OPEN LABLE PHASE II PILOT STUDY OF CARBOPLATIN
Dec 2, 2014Study design: For the pilot trial a single stage phase II design was chosen. All patients that meet the eligibility criteria will receive carboplatin AUC3 until progression (radiological or clinical). A total of 25 patients are required for this stud...
Clinical Studies - Dec 2, 2014 - Dec 31, 2017
Automatically Closed
Project leader: Omlin Aurelius
Members: Gillessen Sommer Silke, Haile Sarah, Jochum Wolfram
MP0250; A phase I multi-centre, open-label, repeated-dose, dose-escalation study to assess safety, tolerability and pharmacokinetics of MP0250 in patients with advanced solid tumours
Oct 23, 2014Dies ist die erste Studie zur Anwendung des neuen Medikaments MP0250 am Menschen. Das Hauptziel ist es, dessen Sicherheit und Verträglichkeit bei Krebs-Patienten zu untersuchen. Diese Studie wird auch prüfen, wie das Medikament durch den Körper verä...
Clinical Studies - Oct 23, 2014 - Sep 30, 2016
Automatically Closed
Project leader: Omlin Aurelius
Members: Hess Dagmar, Jörger Markus, Bickel Angelika
SAKK 63/12 Prospective cohort study with collection of clinical data and serum of patients with prostate disease
Oct 15, 2014Diese Studie umfasst die Erstellung einer Serum- und Gewebebank, sowie die Erhebung zugehöriger klinischer Daten.
Clinical Studies - Oct 15, 2014 - Oct 15, 2024
Automatically Closed
Project leader: Engeler Daniel, Gillessen Sommer Silke
Members: Rothermundt Christian, Omlin Aurelius, Putora Paul Martin, Lengwiler Daniel, Patzl Sigrid, Schaepper Sibylle, Schwab Christoph, Abt Dominik, Templeton Arnoud
LDE225 in combination with Paclitaxel in patients with advanced solid tumors. A multicenter phase I trial
Oct 30, 2013Die Kombination von LDE225 mit Paclitaxel wurde noch nicht getestet und es ist noch nicht bekannt welche Nebenwirkung entstehen können. Man kann noch nicht sicher sagen, dass diese Kombination eine Wirksamkeit bei Patienten mit fortgeschrittenen soli...
Clinical Studies - Oct 30, 2013 - Oct 1, 2015
Automatically Closed
Project leader: Hess Dagmar
Members: Jörger Markus, Omlin Aurelius
Entwicklung von Dienstleistungsmodellen der integrierten Onkologie und Palliative Care: Untersuchung von temporalen Aspekten, Involvierung von Onkologen, und Chemotherapie-Gebrauch
Nov 10, 2010Introduction: Integrated models of oncological palliative care are demanded (Ferris JCO 2009) and currently develop in various settings. Patient-data centered descriptions of concrete service patterns (SePa) may serve this process. We aim to explore...
Clinical Studies - Nov 10, 2010 - Oct 31, 2011
Completed
Project leader: Strasser Florian
Members: Silzle Tobias, Nestor Karen, Köberle Dieter, Omlin Aurelius, Blum David, Linder Susanne, Früh Martin
The European Palliative Care Research Collaborative. Improved treatment of pain, depression and fatigue through translation research
Nov 1, 2006Summary description of project objectives Objective 1 To identify genes and genetic variation relevant for inter-individual variation in opioid responses and genetic variation that may identify patients at particular risk for developing cachexia Obje...
Clinical Studies - Nov 1, 2006 - Oct 31, 2010
Completed
Project leader: Strasser Florian
Members: Linder Susanne, Omlin Aurelius, Oberholzer Rolf, Blum David