Dr. med. Matthias Hoffmann
Unravelling the Evil - the role of CXCL-10 antagonist in HIV+ failing immune recovery despite cART
Jul 1, 2013Although highly active antiretroviral therapy (HAART) leads in general to CD4+ T-cell recovery and decrease of general immune activation, therefore improving individuals’ long-term prognosis, in a clinically significant percentage of 20% of HIV-infec...
Fundamental Research - Jul 1, 2013 - Apr 30, 2014
Automatically Closed
Project leader: Hoffmann Matthias
Members: Schmid Patrick, Kahlert Christian, Vernazza Pietro
Prevention of hepatitis C virus (HCV) and HIV-1 co-infections through induction of potent T cell responses using prime-boost viral vector vaccine regimens (PEACHI)
Feb 1, 2013The goal of the PEACHI project funded by the European Commission (FP7 framework) is to develop simple, affordable and effective vaccine strategies that can be given alone or in combination to prevent hepatitis C virus (HCV), human immunodeficiency vi...
Clinical Studies - Feb 1, 2013 - Sep 27, 2022
Automatically Closed
Project leader: Dorrell Lucy, Barnes Ellie, Hoffmann Matthias, Bergin Colm, Folgori Antonella
Members: Schmid Patrick, Vernazza Pietro
Polyfunctional T-cell profile and its association with antibody titers in HIV-infected individuals with low CD4-nadir after seasonal influenza vaccination (FLUvaccHIV)
Nov 12, 2012BACKGROUND INFORMATION Influenza-vaccination is one of the most potent preventive measures to protect vulnerable populations, e.g. HIV-infected patients. Nevertheless it is unknown if the immune system in HIV-infected patients is restored upon HIV t...
Fundamental Research - Nov 12, 2012 - Jul 12, 2013
Automatically Closed
Project leader: Hoffmann Matthias
Interferon-γ Release Assay (IGRA) Negativity Rates after TB-Treatment in HIV-infected Individuals
Aug 15, 2012Background: Interferon-γ Release assays (IGRA) have partly replaced conventional tuberculin skin tests (TST) in the recent years due to their higher specificity and standardised test procedures including a positive / negative control. Nevertheless it...
Clinical Studies - Aug 15, 2012 - Aug 31, 2013
Automatically Closed
Project leader: Hoffmann Matthias
Members: Ruhwald Morten, Hasse Barbara, Fenner Lukas, Schmid Patrick, Vernazza Pietro
Does hyper-thermal incubation and blockage of T-cell inhibitory pathways improve current and future T-cell based diagnostic test systems?
Feb 1, 2011Background: Cell mediated immune (CMI) assays are important research tools to monitor T-cell dependent immune responses towards specific antigens. Recently CMI assays were introduced for the diagnosis of latent tuberculosis infection (LTBI). In these...
Fundamental Research - Feb 1, 2011 - Dec 31, 2014
Completed
Project leader: Ruhwald Morten, Schoch Otto, Hoffmann Matthias
Functional CD8+ T-Cell Avidity in Association with CD4-Nadir and Viral Immune Escape in Chronically Infected HIV-positive Patients
Jan 11, 2011Rationale: Accumulating evidence underlines the importance of a functional highly avid CD8+ HIV-specific T-cell response in the initial containment of human immunodeficiency virus (HIV) infection. During the time course of infection HIV-specific but...
Fundamental Research - Jan 11, 2011 - Dec 31, 2011
Completed
Project leader: Hoffmann Matthias
Molecular and clinical epidemiology of tuberculosis in Switzerland: Studies of populations infected and not infected with HIV
Sep 1, 2009Tubekulose (TB) ist eine der häufigsten Infektionskrankheiten weltweit. Die TB kann sich unterschiedlich manifestieren, beeinflusst durch bakteriellen Faktoren und die hervorgerufenen Immunantwort. Die Studie untersucht die genetische Populationsstru...
Clinical Studies - Sep 1, 2009 - Dec 31, 2010
Completed
Project leader: Hoffmann Matthias